Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.

A L Hodgson; M Tachedjian; L A Corner; A J Radford

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Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.

机译：通过单次口服活体重组假性棒状杆菌保护绵羊免受干酪样淋巴结炎的侵害。

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An inactive form of the Corynebacterium pseudotuberculosis phospholipase D (PLD) gene was constructed and expressed in a PLD-negative strain (designated Toxminus) of C. pseudotuberculosis. Antibody responses specific to Toxminus and both Toxminus and PLD proteins were detected in sheep following oral administration of Toxminus or Toxminus expressing the PLD toxoid, respectively. However, only those sheep vaccinated with Toxminus expressing PLD toxoid were protected against wild-type challenge. These results confirm the importance of PLD as a protective antigen and demonstrate both the potential for developing an oral caseous lymphadenitis vaccine and C. pseudotuberculosis Toxminus as a live vaccine vector.

机译：构建假形式的棒状杆菌磷脂酶D（PLD）基因的非活性形式，并在假结核杆菌的PLD阴性菌株（称为Toxminus）中表达。在分别口服表达PLD类毒素的Toxminus或Toxminus后，分别在绵羊中检测到对Toxminus以及Toxminus和PLD蛋白都有特异性的抗体反应。但是，只有那些接种了表达Toxminus的PLD类毒素的绵羊才可以免受野生型攻击。这些结果证实了PLD作为保护性抗原的重要性，并证明了开发口服干酪型淋巴结炎疫苗和作为活疫苗载体的假结核梭菌的潜力。

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《Infection and immunity》 |1994年第12期|共6页
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A L Hodgson; M Tachedjian; L A Corner; A J Radford;
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中图分类医学免疫学;
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1. Development of an ELISA using the recombinant protein CP1957 of Corynebacterium pseudotuberculosis for diagnosis of caseous lymphadenitis in sheep [J] . Carlos Guilherme Rosa Reis, Henrique Ramos Angelo, Andréa de Fátima Silva Rezende, BMC proceedings. . 2014,第S4期

机译：利用假结核杆菌重组蛋白CP1957诊断绵羊干酪性淋巴结炎的ELISA方法的建立
2. Corynebacterium pseudotuberculosis secreted antigen-induced specific gamma-interferon production by peripheral blood leukocytes: potential diagnostic marker for caseous lymphadenitis in sheep and goats. [J] . Reboucas M. F., Portela R. W., Lima D. D., Journal of Veterinary Diagnostic Investigation . 2011,第2期

机译：假结核棒杆菌分泌抗原诱导的外周血白细胞产生的特定γ-干扰素：绵羊和山羊干酪性淋巴结炎的潜在诊断标记。
3. Genotypic comparison between Corynebacterium pseudotuberculosis samples obtained from sheep and goats with caseous lymphadenitis, raised in the semi-arid region of Pernambuco [J] . Abreu Sílvio Romero de O., Araújo Flábio R., Castro Roberto S. de, Pesquisa Veterinaria Brasileira . 2008,第10期

机译：伯南布哥州半干旱地区绵羊和山羊患有干酪性淋巴结炎的假结核杆菌样本的基因型比较
4. PARAMETER ESTIMATION OF A MATHEMATICAL MODEL OF CASEOUS LYMPHADENITIS TRANSMISSION IN SHEEP [C] . K. M. OREILLY, L. E. GREEN, F. E. MALONE, Meeting of the Society for Veterinary Epidemiology and Preventive Medicine . 2006

机译：羊皮淋巴结炎数学模型的参数估计
5. CASEOUS LYMPHADENITIS IN SMALL RUMINANTS: CLINICAL, PATHOLOGICAL, AND IMMUNOLOGICAL RESPONSES TO CORYNEBACTERIUM PSEUDOTUBERCULOSIS AND TO FRACTIONS AND TOXINS FROM THE MICROORGANISM. [D] . HSU, TSUEY-YING. 1984

机译：小反刍动物中的淋巴结炎：对棒状杆菌结核杆菌以及微生物分离物和毒素的临床，病理和免疫学反应。
6. Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis. [O] . A L Hodgson, M Tachedjian, L A Corner, 1994

机译：通过单次口服活体重组假性棒状杆菌对绵羊预防干酪样淋巴结炎。
7. Development of an ELISA using the recombinant protein CP1957 of Corynebacterium pseudotuberculosis for diagnosis of caseous lymphadenitis in sheep [O] . Carlos Rosa Reis, Henrique Ramos Angelo, Andréa Silva Rezende, 2014

机译：利用假结核棒杆菌CP1957重组蛋白诊断绵羊干酪性淋巴结炎的ELISA方法的建立

Protection of sheep against caseous lymphadenitis by use of a single oral dose of live recombinant Corynebacterium pseudotuberculosis.

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