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首页> 外文期刊>Infection and immunity >Blood transfusion alters the course and outcome of Plasmodium chabaudi AS infection in mice.
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Blood transfusion alters the course and outcome of Plasmodium chabaudi AS infection in mice.

机译：输血改变了鼠中的chabaudi疟原虫AS感染的过程和结果。

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The importance of severe anemia in the mortality of susceptible A/J mice during blood-stage Plasmodium chabaudi AS infection was assessed. Blood transfusion during and 2 to 3 days after peak parasitemia rescued 90% of susceptible mice from severe anemia and death and allowed these mice to clear the infection and acquire immunity to reinfection. However, blood transfusion prolonged the patency of the infection for up to 5 days after peak parasitemia. Blood transfusions in resistant C57BL/6 mice produced an identical effect, that is, prolongation of the patency of parasitemia. In addition, blood transfusion increased the numbers of gametocytes in both mouse strains. In both strains of mice, the rapid reduction in parasitemia, which occurs during crisis, was associated with the development of moderate levels of anemia. The possible mechanisms for the modulation of parasitemia by blood transfusion and the implications of the present observations for our understanding of the events which occur during crisis are discussed. It is proposed that parasitologic crisis is induced and/or maintained by physiological alterations associated with anemia.
机译：评估了严重贫血在血液阶段Chabaudi疟原虫感染期间易感A / J小鼠死亡率中的重要性。最高寄生虫血症期间和之后的2至3天输血使90％的易感小鼠摆脱了严重的贫血和死亡，并使这些小鼠清除感染并获得了重新感染的免疫力。然而，输血在寄生虫高峰后最多可将感染的开放时间延长5天。抗性C57BL / 6小鼠的输血产生相同的效果，即延长了寄生虫病的通畅时间。另外，输血增加了两种小鼠品系中配子体的数量。在这两种小鼠中，危机期间发生的寄生虫病迅速减少与中等程度的贫血的发展有关。讨论了通过输血调节寄生虫病的可能机制，以及本观察结果对我们理解危机期间发生的事件的意义。建议通过与贫血有关的生理变化来诱发和/或维持寄生虫学危机。

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