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首页> 外文期刊>Infection and immunity >Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells.
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Characterization of Candida albicans mannan-induced, mannan-specific delayed hypersensitivity suppressor cells.

机译：表征白色念珠菌甘露聚糖诱导的，甘露聚糖特异性迟发型超敏反应抑制细胞。

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We have shown previously that CBA/J mice immunized with Candida albicans developed delayed hypersensitivity (DH) demonstrable with mannan (MAN) extracted from the same organism and that the intravenous (i.v.) injection of MAN prior to or during the immunization phase resulted in the suppression of the MAN-specific DH response. In this study, we demonstrate that MAN-induced suppression of DH is a T-lymphocyte-mediated phenomenon. Suppressor cells induced in vivo by the i.v. injection of MAN into naive mice 1 to 7 days prior to harvest were passaged through nylon wool, treated with various surface-specific antibodies and complement, and then injected i.v. into immunized syngeneic recipients. Enrichment of splenic T cells by passage over nylon wool and transfer of the nylon-wool-nonadherent populations to immunized recipient mice suppressed DH in a dose-dependent manner. Depletion of Thy+ or Lyt-2+ cells from nylon-wool-nonadherent populations regularly ablated the ability of such suspensions to transfer suppression. Treatment of the same transfer suspensions with anti-Lyt-1 had variable effects, suggesting that the surface density of the Lyt-1 antigen was not as constant from population to population as was the Lyt-2 antigen. In addition, C. albicans MAN-induced suppressor cells were able to suppress DH demonstrable with Candida tropicalis MAN in animals immunized with C. tropicalis. Suppression of DH by MAN in this model, therefore, is mediated by Thy+ Lyt-2+ lymphocytes.
机译：先前我们已经证明，用白色念珠菌免疫的CBA / J小鼠出现了迟发性超敏反应（DH），可证明是从同一生物中提取的甘露聚糖（MAN）所致，并且在免疫阶段之前或之中，静脉内（iv）注射MAN导致了抑制MAN特异的DH反应。在这项研究中，我们证明MAN诱导的DH抑制是T淋巴细胞介导的现象。 i.v.体内诱导的抑制细胞在收获前1到7天，将MAN注射到幼鼠中，使其通过尼龙毛，用各种表面特异性抗体和补体处理，然后静脉注射。进入免疫的同系受体。通过穿过尼龙毛的富集脾脏T细胞和将尼龙毛非粘附种群转移到免疫的受体小鼠上，可以剂量依赖性抑制DH。来自尼龙-羊毛-非粘附种群的Thy +或Lyt-2 +细胞的耗竭通常会消除这种悬浮液转移抑制的能力。用抗Lyt-1处理相同的转移悬浮液具有不同的效果，这表明Lyt-1抗原的表面密度与Lyt-2抗原不同，种群之间的密度不同。另外，白色念珠菌MAN诱导的抑制细胞能够抑制热带念珠菌MAN证实的在用热带念珠菌免疫的动物中的DH。因此，在该模型中MAN对DH的抑制作用是由Thy + Lyt-2 +淋巴细胞介导的。

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