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首页> 外文期刊>Infection and immunity >A surface protein expressed during the transformation of zygotes of Plasmodium gallinaceum is a target of transmission-blocking antibodies.
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A surface protein expressed during the transformation of zygotes of Plasmodium gallinaceum is a target of transmission-blocking antibodies.

机译：鸡疟原虫合子转化过程中表达的表面蛋白是传递阻断抗体的靶标。

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摘要

Antibodies against gametes of malarial parasites (Plasmodium spp.) have previously been shown to block infectivity of the parasites to mosquitoes by preventing fertilization of the parasites in the insect midgut. These antibodies did not have any effect on the development of fertilized parasites. We now report that a surface protein of Mr 26,000 synthesized by zygotes of P. gallinaceum is the target of antibodies which block infectivity of the fertilized parasites to mosquitoes. Identification of this target antigen offers a new stage of the parasite against which a malaria transmission-blocking vaccine could be developed.
机译：先前已经显示出针对疟原虫的配子的抗体（Plasmodium spp。）可通过阻止昆虫中肠中的寄生虫受精来阻止寄生虫对蚊子的感染。这些抗体对受精寄生虫的发育没有任何影响。我们现在报告说，由P. gallinaceum的受精卵合成的Mr 26,000的表面蛋白是阻断受精寄生虫对蚊子传染性的抗体的靶标。鉴定该靶抗原提供了寄生虫的新阶段，可以针对该寄生虫开发阻断疟疾的疫苗。

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