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Developmental Changes in the Circumsporozoite Proteins of Plasmodium Berghei andP. Gallinaceum in their Mosquito Vectors

机译：疟原虫环状子孢子蛋白的发育变化。 Gallinaceum在他们的蚊子矢量

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The circumsporozoite (CS) protein covers the surface of the sporozoite ofplasmodia. Its role in the development of the malaria parasite in mosquito vectors remains unknown. CS-epitope-containing proteins appear on undifferentiated oocysts on day 7 in Plasmodium berghei and on day 5 in P. gallinaceum as demonstrated by indirect fluorescence antibody tests using monoclonal antibodies directed against the CS-protein repeats. The three-dimensional distribution of the CS-epitope-containing proteins on oocysts was analyzed by confocal scanning laser microscopy. A strong antibody binding was found in patches around the oocysts of P. berghei and P. gallinaceum, and an accumulation of labeled proteins was found at the base of the oocysts of both species. In Western blots of infected midguts and salivary glands the antibodies recognized two peptides in the salivary glands but up to ten peptides in midgut extracts. The larger number of peptides recognized in midgut preparations might indicate breakdown products during the escape of the sporozoites from the oocyst and their migration on the midgut in the mosquito vector. The data indicate a possible involvement of the CS protein in an active migration process of the sporozoites in the mosquito vector.

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Boulanger, N.; Charoenvit, Y.; Krettli, A.; Betschart, B.;
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年度 1995
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总页数 9
原文格式 PDF
正文语种 eng
中图分类工业技术;
关键词
Parasites; Sporozoites; Plasmodium berghei; Mosquito borne diseases; Test andevaluation; Spatial distribution; Fluorescence; Preparation; Degradation; Peptides; Proteins; Three dimensional; Antibodies; Migration; Monoclonal antibodies; Malaria; Accumulati;

机译：寄生虫;子孢子;伯氏疟原虫;蚊媒疾病;试验和评价;空间分布;荧光;制备;降解;肽;蛋白质;三维;抗体;迁移;单克隆抗体;疟疾;累积;

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专利

1. Motility and infectivity of Plasmodium berghei sporozoites expressing avian Plasmodium gallinaceum circumsporozoite protein [J] . Tewari R, Rathore D, Crisanti A Cellular microbiology . 2005,第5期

机译：表达鸟类疟原虫环子孢子蛋白的伯氏疟原虫子孢子的运动性和感染性
2. A conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge. [J] . S Chatterjee, M Wery, P Sharma, Infection and immunity . 1995,第11期

机译：恶性疟原虫环子孢子蛋白和抗肽抗体的保守肽序列抑制伯氏疟原虫子孢子侵袭Hep-G2细胞，并保护免疫小鼠免受伯氏疟原虫子孢子攻击。
3. The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of Plasmodium berghei and Plasmodium falciparum [J] . Marianne Patricia Ntsama epse Foh Mengo, Giampietro Corradin, Silayuv Bongfen Research Journal of Biological Sciences . 2008,第12期

机译：伯氏疟原虫和恶性疟原虫环子孢子（CSP）的免疫应答和（Nt + Ct）蛋白混合物的影响评估
4. Examination of Plasmodium berghei oocysts in the mosquito vector using MALDI Fourier Transform Imaging Mass Spectrometry [C] . Berin Boughton, Daniel Sarabia, Dean Goodman, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用MALDI傅里叶变换成像质谱法检测蚊子载体中Perghei卵囊的检查
5. 1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites. [D] . Natarajan, Ramya. 2006

机译：1.伯氏疟原虫环子孢子蛋白（CSP）的蛋白水解加工位点中突变体的产生和表征。 2.伯氏疟原虫子孢子荧光体和促红细胞生成前阶段：研究蚊子和哺乳动物宿主与疟原虫相互作用的新工具。
6. A conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge. [O] . S Chatterjee, M Wery, P Sharma, 1995

机译：恶性疟原虫环子孢子蛋白和抗肽抗体的保守肽序列抑制伯氏疟原虫子孢子侵袭Hep-G2细胞并保护免疫小鼠免受伯氏疟原虫子孢子攻击。
7. A conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge [O] . S Chatterjee, M Wery, P Sharma, 1995

机译：疟原虫植入疟原虫蛋白质和抗肽抗体的保守肽序列抑制苯乙烯孢子素侵袭Hep-G2细胞的侵袭，并保护免疫小鼠免受P. Berghei孢子挑战的攻击
8. T Cell Clone Directed at the Circumsporozoite Protein which Protects Mice againstBoth Plasmodium yoelii and Plasmodium berghei. (Reannouncement with New Availability Information) [R] . Weiss, W. R., Berzofsky, J. A., Houghten, R. A., 1992

机译：T细胞克隆针对环子孢子蛋白，保护小鼠免受约氏疟原虫和伯氏疟原虫的侵害。（重新公布新的可用性信息）

Developmental Changes in the Circumsporozoite Proteins of Plasmodium Berghei andP. Gallinaceum in their Mosquito Vectors

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