Examination of Plasmodium berghei oocysts in the mosquito vector using MALDI Fourier Transform Imaging Mass Spectrometry

机译：使用MALDI傅里叶变换成像质谱法检测蚊子载体中Perghei卵囊的检查

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New method to examine plasmodium metabolism in situ in the mosquito developed. Distinct differences in the phospholipid and FA profile of infected vs control midguts. Infected midguts display an increase in pro-inflammatory FA content, particularly AA. Imaging MS identified 28 species in higher abundance in the infected midgut. A distinct PE(38:5) species found localised to infection site. Tandem MS/MS analysis showed a 4:1 ratio of EPA vs AA at Sn2 position. EPA is a PUFA that suppresses immune response via oxidative metabolism products. Ongoing investigations are exploring the temporal changes in lipid content to better understand their roles.

机译：在蚊子发达的蚊子原位中检查疟原虫代谢的新方法。感染的VS控制中肠的磷脂和FA轮廓的明显差异。受感染的中肠显示出促炎的FA含量增加，特别是AA。在感染的中间肠道中，MS鉴定了28种较高丰度的物种。发现局部化为感染部位的不同PE（38：5）。串联MS / MS分析显示EPA与SN2位置的4：1比例。 EPA是抑制通过氧化代谢产品抑制免疫应答的PUFA。正在进行的调查正在探索脂质含量的时间变化，以更好地了解其角色。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2015年||共1页
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Berin Boughton; Daniel Sarabia; Dean Goodman; Mark Condina; Geoff McFadden; Ute Roessner;
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机译：内部MALDI源傅里叶变换离子回旋共振质谱法测量MALDI / LDI离子的初始速度分布
3. Improvement of the observational method for Plasmodium berghei oocysts in the midgut of mosquitoes [J] . Miho Usui, Shinya Fukumoto, Noboru Inoue, Parasites Vectors . 2011,第1期

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4. Examination of Plasmodium berghei oocysts in the mosquito vector using MALDI Fourier Transform Imaging Mass Spectrometry [C] . Berin Boughton, Daniel Sarabia, Dean Goodman, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

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5. 1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites. [D] . Natarajan, Ramya. 2006

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机译：潜在指纹的化学表征，包括基质辅助激光解吸电离，飞行时间二次离子质谱，兆电子伏特二次质谱，气相色谱/质谱，X射线光电子能谱和衰减全反射傅里叶变换红外光谱成像：比较
8. Developmental Changes in the Circumsporozoite Proteins of Plasmodium Berghei andP. Gallinaceum in their Mosquito Vectors [R] . Boulanger, N., Charoenvit, Y., Krettli, A., 1995

机译：疟原虫环状子孢子蛋白的发育变化。 Gallinaceum在他们的蚊子矢量

Examination of Plasmodium berghei oocysts in the mosquito vector using MALDI Fourier Transform Imaging Mass Spectrometry

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