• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Augmentation of host resistance to microbial infections by recombinant human interleukin-1 alpha.
【24h】

Augmentation of host resistance to microbial infections by recombinant human interleukin-1 alpha.

机译：重组人白介素-1α增强了宿主对微生物感染的抵抗力。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recombinant human interleukin-1 alpha augmented resistance of mice to microbial infections caused by Pseudomonas aeruginosa, Klebsiella pneumoniae, Staphylococcus aureus, Streptococcus pneumoniae, Salmonella typhimurium, and Candida albicans. The effective doses of interleukin-1 alpha ranged from 0.01 to 10 micrograms per mouse, depending on the infecting organism, route of administration, and challenge dose. Intravenous interleukin-1 alpha was, dose for dose, more effective than intravenous muramyl dipeptide and lentinan against the P. aeruginosa and K. pneumoniae infections. Augmentation by interleukin-1 alpha of resistance to infection was also observed in P. aeruginosa-infected mice in a state of cyclophosphamide-induced leucopenia. Interleukin-1 alpha may be useful for controlling obstinate infections not curable by antimicrobial agents alone.
机译：重组人白介素-1α增强了小鼠对由铜绿假单胞菌，肺炎克雷伯菌，金黄色葡萄球菌，肺炎链球菌，鼠伤寒沙门氏菌和白色念珠菌引起的微生物感染的抵抗力。白细胞介素-1α的有效剂量为每只小鼠0.01到10微克不等，具体取决于感染生物，给药途径和攻击剂量。静脉内白介素-1α的剂量比静脉内的聚戊二酰二肽和香菇多糖对铜绿假单胞菌和肺炎克雷伯菌感染更有效。在环磷酰胺诱导的白细胞减少症的状态下，在铜绿假单胞菌感染的小鼠中也观察到白介素-1α增强了对感染的抵抗力。白介素-1α可用于控制不能由单独的抗微生物剂治愈的顽固性感染。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号