Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting.

P C Melby; D L Sacks

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Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting.

机译：鉴定人类利什曼病中T细胞识别的抗原：通过免疫印迹分析T细胞克隆。

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Immunity in human leishmaniasis is mediated by sensitized T lymphocytes; however, the antigens involved in eliciting this immunity have not been defined. We describe the generation of human T-lymphocyte clones derived from two patients with healed leishmaniasis. By use of one- and two-dimensional cellular immunoblotting techniques, we directly identified the parasite antigens recognized by these clones. To our knowledge, these are the first leishmanial antigens identified to which CD4+, gamma interferon-producing T cells from immune individuals have been shown to respond, the strategy may be of general use for the identification of antigens involved in immunity in this disease.

机译：人类利什曼病的免疫是由致敏的T淋巴细胞介导的。然而，尚未定义引起这种免疫力的抗原。我们描述了人类T淋巴细胞克隆的产生，该克隆来自两名患有利什曼病的患者。通过使用一维和二维细胞免疫印迹技术，我们直接鉴定了这些克隆识别的寄生虫抗原。据我们所知，这些是最早鉴定出的利什曼原虫抗原，已证明对来自免疫个体的CD4 +，产生γ干扰素的T细胞有反应，该策略可能普遍用于鉴定与该疾病免疫力有关的抗原。

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《Infection and immunity》 |1989年第10期|共6页
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P C Melby; D L Sacks;
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中图分类医学免疫学;
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1. Characterization of a unique T-cell clone established from a patient with HAM/TSP which recognized HTLV-I-infected T-cell antigens as well as spinal cord tissue antigens. [J] . Nagai M, Yashiki S, Fujiyoshi T, Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 1996,第2期

机译：从患有HAM / TSP的患者建立的独特T细胞克隆的表征，该克隆识别HTLV-1感染的T细胞抗原以及脊髓组织抗原。
2. CD4+ T-cell clones recognizing human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells. [J] . Long HM, Zuo J, Leese AM Blood: The Journal of the American Society of Hematology . 2009,第4期

机译：识别人类淋巴瘤相关抗原的CD4 + T细胞克隆：通过体外用自体爱泼斯坦-巴尔病毒转化的B细胞进行刺激产生。
3. Antigenic Properties and Processing Requirements of 65-Kilodalton Mannoprotein, a Major Antigen Target of Anti-Candida Human T-Cell Response, as Disclosed by Specific Human T-Cell Clones [J] . Roberto Nisini, Giulia Romagnoli, Maria Jesus Gomez, Infection and immunity . 2001,第6期

机译：特定人类T细胞克隆揭示的65千甘露聚糖蛋白的抗原性和加工要求，这是抗念珠菌人类T细胞反应的主要抗原靶标。
4. Adoptive Immunotherapy of Human Diseases with Antigen-Specific T-Cell Clones [C] . Stanley R. Riddell, Edus H. Warren, Deborah Lewinsohn, Keio International Symposium for Life Sciences and Medicine . 2000

机译：用抗原特异性T细胞克隆采用人类疾病的免疫治疗
5. Analysis of supernumerary clonal gamma T-cell receptor gene rearrangements in cutaneous T-cell lymphoma [D] . Tolpinrud, Whitney Lynn 2011

机译：皮肤T细胞淋巴瘤中叠加克隆γT细胞受体基因重排分析
6. Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting. [O] . P C Melby, D L Sacks 1989

机译：鉴定人类利什曼病中T细胞识别的抗原：通过免疫印迹分析T细胞克隆。
7. Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting [O] . P C Melby, D L Sacks 1989

机译：T细胞在人Leishmaniaisis中识别的抗原：免疫印迹T细胞克隆分析
8. Heterogeneity of CD4-Positive Human T-Cell Clones Which Recognize the Surface Protein Antigen of 'Rickettsia typhi' [R] . Carl, M., Vaidya, S., Robbins, F. M., 1989

机译：识别“伤寒立克次体”表面蛋白抗原的CD4阳性人T细胞克隆的异质性

Identification of antigens recognized by T cells in human leishmaniasis: analysis of T-cell clones by immunoblotting.

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