• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Immunoprophylaxis of Chlamydia trachomatis lymphogranuloma venereum pneumonitis in mice by oral immunization.
【24h】

Immunoprophylaxis of Chlamydia trachomatis lymphogranuloma venereum pneumonitis in mice by oral immunization.

机译：通过口服免疫对小鼠沙眼衣原体淋巴肉芽肿性肺炎的免疫预防。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Groups of BALB/c mice were orally immunized with chlamydiae and challenged intranasally to determine whether oral immunization offers protection against pulmonary disease and to characterize the nature and kinetics of the chlamydial antibody response in the lung and other mucosal sites. Protection by oral immunization from chlamydial lung disease was demonstrated by lack of replication of the organism and the lack of chlamydial antigen in lung tissue. The chlamydial immunoglobulin A (IgA) antibody response was present at all body sites, reaching peak levels in the lung as well as in the serum. Classical IgA booster effect kinetics was observed after intranasal challenge, especially in the lung. Specific IgG antibody was detected at all body sites but at lower levels. Furthermore, animals immunized orally had no pneumonic process, as determined by histopathology. These studies also suggest that passively acquired specific serum IgG antibody may not significantly influence the course of mucosal replication of the organism. These observations indicate that oral immunization activating the gut-associated lymphoid tissue system gave total protection against chlamydial lung disease, suggesting migration of immunologically competent cells from the intestine to the lung.
机译：用衣原体口服免疫BALB / c组小鼠，然后鼻内攻击，以确定口服免疫是否可预防肺部疾病，并表征肺和其他粘膜部位衣原体抗体反应的性质和动力学。通过缺乏机体的复制和肺组织中缺乏衣原体抗原，证明了通过口服免疫预防衣原体肺病。衣原体免疫球蛋白A（IgA）抗体反应存在于所有身体部位，在肺以及血清中均达到峰值。在鼻内攻击后，尤其是在肺中，观察到经典的IgA增强效应动力学。在所有身体部位均检测到特异性IgG抗体，但水平较低。此外，经组织病理学确定，口服免疫的动物没有肺炎过程。这些研究还表明，被动获得的特异性血清IgG抗体可能不会显着影响生物体黏膜复制的过程。这些观察结果表明，激活肠道相关淋巴样组织系统的口服免疫可提供针对衣原体肺疾病的全面保护，这表明具有免疫功能的细胞从肠道向肺部迁移。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号