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首页> 外文期刊>Infection and immunity >Anti-Borrelia burgdorferi antibody response over the course of Lyme neuroborreliosis.
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Anti-Borrelia burgdorferi antibody response over the course of Lyme neuroborreliosis.

机译：抗莱氏疏螺旋体抗体在莱姆病神经疏螺旋体过程中的反应。

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Characteristic findings on examination of cerebrospinal fluid (CSF) in Lyme neuroborreliosis include mononuclear pleocytosis, oligoclonal immunoglobulin G (IgG) bands, and evidence for local production of specific antibodies. We utilized an immunospot assay to detect cells secreting anti-Borrelia burgdorferi antibodies of different isotypes over the course of disease. Such cells were detected in CSF from 13 consecutive patients with neuroborreliosis examined before treatment. IgG antibody-secreting cells were present in high numbers (mean, 32 cells per 10(4) CSF cells), whereas IgA and IgM antibody-secreting cells were found less frequently and at lower numbers (mean, 5 and 6 cells per 10(4) CSF cells, respectively). Clinical improvement after penicillin treatment was paralleled by a rapid decline of antibody-secreting cells in CSF, but they were still detected, although at lower numbers, in 5 of 10 patients examined more than 6 months after treatment. This specific B-cell response persisted despite clinical improvement. Whether it reflects persistence of antigen is unsettled.
机译：莱姆神经病的脑脊髓液（CSF）检查的特征性发现包括单核细胞增多，寡克隆免疫球蛋白G（IgG）谱带以及局部产生特异性抗体的证据。我们利用免疫斑点测定来检测在疾病过程中分泌不同同型抗伯氏疏螺旋体抗体的细胞。在治疗前检查了连续13例神经衰弱患者的CSF中发现了此类细胞。分泌IgG抗体的细胞数量很高（平均每10（4）个CSF细胞32个细胞），而分泌IgA和IgM的抗体细胞的频率更低，数量也较低（平均每10（5和6个细胞）（ 4）分别是CSF细胞）。青霉素治疗后的临床改善与脑脊液中抗体分泌细胞的迅速减少相提并论，但在治疗后6个月以上的10例患者中，有5例仍被检出，尽管数量较少。尽管临床上有所改善，但这种特定的B细胞反应仍然持续。是否反映抗原的持久性尚未确定。

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