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首页> 外文期刊>Infection and immunity >Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model.
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Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model.

机译：白细胞介素6在脂多糖-半乳糖胺败血性休克模型中的保护作用。

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C57BL/6J mice given low doses of lipopolysaccharide (LPS) (100 ng per mouse) plus D-galactosamine (8 mg per mouse) die within 24 h following LPS administration. We used this septic shock model to confirm the role of tumor necrosis factor in mortality using a monoclonal antibody to tumor necrosis factor to prevent lethality. Furthermore, we demonstrated that interleukin 6, rather than playing a lethal role, protected mice against death in this septic shock model. Antibody to interleukin 6 did not affect the fatal outcome in this low-LPS-dose model. However, pretreatment with antibody to tumor necrosis factor did protect the mice against death, in a dose-dependent manner. Moreover, mortality was enhanced by pretreatment with antibody to interleukin 6 when tumor necrosis factor was partly limited by anti-tumor necrosis factor treatment. Mortality was significantly reduced by pretreatment with both recombinant interleukin 6 and low doses of antibody to tumor necrosis factor; in the absence of the low dose of antibody to tumor necrosis factor, interleukin 6 alone did not confer any protection. These data demonstrate in vivo antagonistic activities of tumor necrosis factor and interleukin 6 and show that interleukin 6 can play a protective role against death from septic shock.
机译：给予低剂量脂多糖（LPS）（每只小鼠100 ng）加D-半乳糖胺（每只小鼠8 mg）的C57BL / 6J小鼠在LPS给药后24小时内死亡。我们使用这种败血性休克模型来证实肿瘤坏死因子在死亡率中的作用，使用针对肿瘤坏死因子的单克隆抗体来防止致死性。此外，我们证明了在这种败血性休克模型中，白介素6可以起到保护小鼠免于死亡的作用，而不是发挥致命作用。在这种低LPS剂量模型中，白介素6抗体不会影响致命结果。然而，用抗肿瘤坏死因子的抗体预处理确实以剂量依赖的方式保护了小鼠免于死亡。此外，当肿瘤坏死因子部分地受到抗肿瘤坏死因子治疗的限制时，用抗白介素6抗体预处理可提高死亡率。重组白介素6和低剂量抗肿瘤坏死因子抗体预处理可显着降低死亡率。在缺乏低剂量的肿瘤坏死因子抗体的情况下，仅白介素6不能提供任何保护。这些数据证明了肿瘤坏死因子和白介素6的体内拮抗活性，并表明白介素6可以起到抵抗败血性休克死亡的保护作用。

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