Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth.

V Headley; M Hong; M Galko; S M Payne

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Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth.

机译：弗氏志贺氏菌在细胞外和细胞内生长过程中表达航空细菌素基因。

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The expression of the Shigella flexneri chromosomal aerobactin genes during growth of the bacterium within tissue culture cells was assayed. During intracellular growth, aerobactin promoter activity was repressed relative to the level observed in bacteria grown extracellularly, even when the bacteria had been starved for iron prior to infection. Similarly, the level of one of the proteins encoded by this operon, the aerobactin outer membrane receptor, Iut, was reduced in the intracellular environment. These studies indicate that the aerobactin system is not highly expressed by bacteria within host cells, suggesting that siderophore-independent iron acquisition systems can provide essential iron during intracellular multiplication.

机译：测定了细菌在组织培养细胞内生长过程中的弗氏志贺氏菌（Shigella flexneri）染色体气杆菌素基因的表达。在细胞内生长期间，相对于在细胞外生长的细菌中观察到的水平，即使当细菌在感染前已经饿死了铁时，航空杆菌素启动子的活性也会受到抑制。同样，在细胞内环境中，该操纵子编码的一种蛋白质，即航空杆菌素外膜受体Iut的水平降低了。这些研究表明，航空细菌素系统在宿主细胞中并未被细菌高度表达，这表明铁载体独立的铁捕获系统可以在细胞内增殖过程中提供必需的铁。

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《Infection and immunity》 |1997年第2期|共4页
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V Headley; M Hong; M Galko; S M Payne;
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中图分类医学免疫学;
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1. The aerobactin iron transport system genes in Shigella flexneri are present within a pathogenicity island. [J] . Vokes SA, Torres AG, Payne SM, Molecular Microbiology . 1999,第1期

机译：弗氏志贺氏菌中的航空细菌素铁转运系统基因存在于致病岛中。
2. Resistance to fluoroquinolones by the combination of target site mutations and enhanced expression of genes for efflux pumps in Shigella flexneri and Shigella sonnei strains isolated in Korea. [J] . Kim JY, Kim SH, Jeon SM, Clinical microbiology and infection: European Society of Clinical Microbiology and Infectious Diseases . 2008,第8期

机译：在韩国分离的弗氏志贺氏菌和志贺氏志贺氏菌菌株中，结合靶位点突变和外排泵基因的增强表达，对氟喹诺酮类药物具有耐药性。
3. MxiE Regulates Intracellular Expression of Factors Secreted by the Shigella flexneri 2a Type III Secretion System [J] . Colleen D. Kane, Raymond Schuch, William A. Day, Journal of bacteriology . 2002,第16期

机译：MxiE调节弗氏志贺氏菌2a型III分泌系统分泌的因子的细胞内表达。
4. SCALE-UP CONSIDERATIONS AND INVESTIGATION OF THE BIOCONJUGATION OF A SEMI-SYNTHETIC SHIGELLA FLEXNERI TYPE 2A CONJUGATE VACCINE UNDER GMP GUIDELINES [C] . Robert M. F. van der Put, Carolien Smitsman, Olga Ophorst International Carbohydrate Symposium . 2018

机译：在GMP指南下，半合成志贺氏菌型2A缀合物疫苗生物缀合的扩展考虑和调查
5. The role of innate and adaptive immune mediators in the intracellular recognition of Shigella flexneri [D] . Jehl, Stephanie Patrice 2011

机译：先天性和适应性免疫介质在弗氏志贺氏菌细胞内识别中的作用
6. Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth. [O] . V Headley, M Hong, M Galko, 1997

机译：弗氏志贺氏菌在细胞外和细胞内生长过程中表达航空细菌素基因。
7. Differential protein expression by Shigella flexneri in intracellular and extracellular environments. [O] . Headley, V L, Payne, S M 1990

机译：弗氏志贺氏菌在细胞内和细胞外环境中的差异蛋白表达。
8. Synthesis of Aerobactin and a 76,000-Dalton Iron-Regulated Outer Membrane Protein by Escherichia coli K-12-Shigella flexneri Hybrids and by Enteroinvasive Strains of Escherichia coli [R] . Griffiths, E., Stevenson, P., Hale, T. L., 1985

机译：大肠埃希氏菌K-12-shigella flexneri杂交种和大肠杆菌肠道侵袭菌合成aerobactin和76,000-Dalton铁调节的外膜蛋白

Expression of aerobactin genes by Shigella flexneri during extracellular and intracellular growth.

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