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首页> 外文期刊>Infection and immunity >Expansion of a Novel Pulmonary CD3? CD4+CD8+ Cell Population in Mice during Chlamydia pneumoniae Infection
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Expansion of a Novel Pulmonary CD3? CD4+CD8+ Cell Population in Mice during Chlamydia pneumoniae Infection

机译：扩展新型肺CD3？肺炎衣原体感染过程中小鼠的CD4 + CD8 +细胞数量

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A new pulmonary T-cell-like lymphocyte population with the phenotype CD3? CD4+ CD8+ was discovered in mice. CD4+ CD8+ but CD3+ cells among murine intestinal intraepithelial lymphocytes have previously been described. We describe herein a dramatic expansion of the CD3? CD4+CD8+ cell population in response to experimental respiratory infection. After intranasal Chlamydia pneumoniae infection, CD4+ CD8+ cells became transiently the dominant lymphocyte type (maximum of 87% of all lymphocytes) in the lungs of NIH/S mice but remained virtually undetectable in spleen and blood. The enrichment of these cells was not a C. pneumoniae-specific event, since infection of NIH/S mice with influenza A virus also resulted in an increase in the number of CD4+ CD8+ cells (maximum of 42% of all lymphocytes). In addition to outbred NIH/S mice, two other mouse strains were studied: BALB/c (H-2d) and C57BL/6 (H-2b). C. pneumoniae-infected BALB/c mice responded with an intermediate increase in the number of CD4+ CD8+ cells in lungs, whereas C57BL/6 mice did not respond. The double-positive CD4+ CD8+cells lacked a major part of the T-cell receptor complex, being both CD3? and TCR αβ?. However, when they were stimulated in vitro with a T-cell mitogen, they responded by proliferation but did not secrete gamma interferon. The dramatic expansion of this cell population at the infection site suggests an active role for them in respiratory infection, but the specification of this requires further study.
机译：在小鼠中发现了一个新的表型为CD3 ？ CD4 + CD8 + 的肺T细胞样淋巴细胞。先前已经描述了鼠肠上皮内淋巴细胞中的CD4 + CD8 + 细胞，但CD3 + 细胞。我们在此描述了响应实验性呼吸道感染的CD3 ？ CD4 + CD8 + 细胞群的急剧扩展。鼻内肺炎衣原体感染后，CD4 + CD8 + 细胞暂时成为肺中的优势淋巴细胞类型（占所有淋巴细胞的87％） NIH / S小鼠，但实际上在脾脏和血液中仍未检测到。这些细胞的富集不是 C。肺炎特异性事件，因为NIH / S小鼠感染了甲型流感病毒也导致CD4 + CD8 + 细胞数量增加（最大占所有淋巴细胞的42％）。除杂种NIH / S小鼠外，还研究了另外两种小鼠品系：BALB / c（H-2 d ）和C57BL / 6（H-2 b ）。 C。肺炎感染的BALB / c小鼠的肺中CD4 + CD8 + 细胞数量增加，而C57BL / 6小鼠无反应。 CD4 + CD8 + 双阳性细胞缺乏T细胞受体复合物的主要部分，均为CD3 α和TCRαβ< sup>？。但是，当在体外用T细胞促分裂原刺激它们时，它们通过增殖反应，但不分泌γ干扰素。该细胞群在感染部位的急剧增加表明它们在呼吸道感染中起着积极作用，但是对此的规范需要进一步研究。

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