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首页> 外文期刊>Infection and immunity >Characterization of the Murine T-Lymphocyte Response to Salmonella enterica Serovar Typhimurium Infection
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Characterization of the Murine T-Lymphocyte Response to Salmonella enterica Serovar Typhimurium Infection

机译：小鼠沙门氏菌血清型鼠伤寒沙门氏菌感染的T淋巴细胞的表征。

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Infection of mice with Salmonella enterica serotype Typhimurium induces a strong Th1 cell response that is central for the control of infection. We infected mice of a resistant background with a virulent strain of S. enterica serovar Typhimurium and analyzed the kinetics and magnitude of the T-cell response. After infection, the majority of CD4+ and CD8+ splenocytes acquired an activated phenotype, as indicated by expression levels of CD44 and CD62L. In addition, after 3 to 4 weeks of infection, more than 20% of the CD4+ and more than 30% of the CD8+ T cells produced gamma interferon (IFN-γ) in response to short-term polyclonal stimulation. In contrast, we detected only a moderate (two- to threefold) expansion of both T-cell populations, and BrdU incorporation revealed that there was either no or only a limited increase in the in vivo proliferation of CD4+ and CD8+ T cells, respectively. Our results indicate that although an unexpectedly large population of both CD4+ and CD8+ T cells is activated and acquires the potential to secrete IFN-γ, this activation is not paralleled by substantial expansion of these T-cell populations.
机译：鼠伤寒血清型鼠伤寒沙门氏菌感染小鼠会产生强烈的Th1细胞反应，这对于控制感染至关重要。我们用强毒株 S感染了具有抗性背景的小鼠。鼠伤寒鼠伤寒沙门氏菌并分析了T细胞反应的动力学和强度。感染后，大多数CD4 + 和CD8 + 脾细胞获得活化的表型，如CD44和CD62L的表达水平所示。此外，在感染3到4周后，超过20％的CD4 + 和30％的CD8 + T细胞产生了γ干扰素（IFN-γ γ）响应短期多克隆刺激。相比之下，我们只检测到两个T细胞群体都有中等程度的扩展（两倍至三倍），而BrdU的掺入表明CD4 + 和CD8 + T细胞。我们的结果表明，尽管CD4 + 和CD8 + T细胞意外地大量激活并获得了分泌IFN-γ的潜能，但这种激活并不与这些T细胞数量的大幅增长。

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