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首页> 外文期刊>Infection and immunity >Transforming Growth Factor α Binds to Trypanosoma cruzi Amastigotes To Induce Signaling and Cellular Proliferation
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Transforming Growth Factor α Binds to Trypanosoma cruzi Amastigotes To Induce Signaling and Cellular Proliferation

机译：转化生长因子α与克氏锥虫变形虫结合，诱导信号传导和细胞增殖

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摘要

Macrophages secrete transforming growth factor α (TGF-α) to trigger proliferation of cancer cells. Here, we report a new role for TGF-α in modulating the direct cellular proliferation of a parasitic protozoan, Trypanosoma cruzi. Amastigotes present two classes of receptors for TGF-α with different binding affinities. 125I-TGF-α binding was competed by an excess of cold epidermal growth factor and TGF-α but not by an irrelevant molecule. Upon binding of TGF-α to amastigotes, the ligand is internalized, inducing trypanosome tyrosine phosphorylation of 90- and 87-kDa proteins and increasing DNA synthesis and proliferation of amastigotes. Furthermore, exposure of macrophages to TGF-α induced increased amastigote proliferation. These results describe a novel mechanism used by amastigotes to regulate their proliferation mediated by a TGF-α-dependent signal transduction pathway.
机译：巨噬细胞分泌转化生长因子α（TGF-α）以触发癌细胞的增殖。在这里，我们报道了TGF-α在调节寄生原生动物 Trypanosoma cruzi 的直接细胞增殖中的新作用。变形虫呈现出两类具有不同结合亲和力的TGF-α受体。 125 I-TGF-α的结合与过量的冷表皮生长因子和TGF-α竞争，而与无关分子竞争。当TGF-α与变形虫结合后，配体被内化，诱导90-kDa和87-kDa蛋白的锥虫酪氨酸磷酸化，并增加了变形虫的DNA合成和增殖。此外，巨噬细胞暴露于TGF-α诱导了鞭毛体增殖的增加。这些结果描述了一种由amastigotes用来调节由TGF-α依赖性信号转导途径介导的增殖的新机制。

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