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首页> 外文期刊>Infection and immunity >Immunoglobulin G1 (IgG1) and IgG3 antibodies are markers of progressive disease in leprosy.
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Immunoglobulin G1 (IgG1) and IgG3 antibodies are markers of progressive disease in leprosy.

机译：免疫球蛋白G1（IgG1）和IgG3抗体是麻风病中进行性疾病的标志物。

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Mycobacterium leprae-specific and polyclonal immunoglobulin G (IgG) subclass and IgE antibodies in leprosy patients across the histopathological spectrum were determined by using a quantitative enzyme-linked immunosorbent assay. Antibody responses to M. leprae sonicates were detected only in IgG1, -2, and -3 subclasses. Even at 100-times-lower dilutions, very little IgG4 and IgE antibody activity against M. leprae was detected in any group of leprosy patients. Quantitatively, antibody responses were highest at the lepromatous pole and decreased towards the tuberculoid pole. The greatest quantitative difference in antibodies between the lepromatous and tuberculoid poles was observed with IgG1 (140-fold), this was followed by the difference with IgG3 antibodies (32-fold). Polyclonal antibodies, on the other hand, were elevated for all four IgG subclasses as well as IgE in both lepromatous and tuberculoid leprosy patients compared with healthy controls from a leprosy-endemic area. Selective elevation of M. leprae-specific antibody responses in IgG1 and IgG3 subclasses, therefore, could not be attributed to selective polyclonal activation in these particular subclasses. Furthermore, polyclonal activation for IgE was observed in both lepromatous and tuberculoid leprosy patients, with higher levels in the tuberculoid group, which does not support selective TH2 activation in lepromatous leprosy patients. IgG1 and IgG3 antibodies also showed the highest Spearman rank correlation with the bacterial index in these patients (rho = 0.748 and P < 0.001 for IgG1; rho = 0.721 and and P < 0.001 for IgG3). Thus, disease progression in leprosy showed a significant correlation with selective increases in IgG1 and IgG3 responses.
机译：通过使用定量酶联免疫吸附测定法，确定了整个组织病理学范围内麻风病患者的分枝杆菌麻风特异性和多克隆免疫球蛋白G（IgG）亚类和IgE抗体。仅在IgG1，-2和-3亚类中检测到对麻风分枝杆菌的抗体反应。即使以低100倍的稀释度，在任何一组麻风病人中也检测不到针对麻风分枝杆菌的IgG4和IgE抗体活性。在数量上，抗体反应在麻风极最高，而在结核极则下降。 IgG1（140倍）观察到了麻风和结核极之间抗体的最大定量差异，其次是IgG3抗体（32倍）之间的差异。另一方面，与来自麻风流行区的健康对照相比，麻风病和结核性麻风病患者的所有四个IgG亚类以及IgE的多克隆抗体均升高。因此，IgG1和IgG3亚类中麻风杆菌特异性抗体应答的选择性升高不能归因于这些特定亚类中的选择性多克隆激活。此外，在麻风病和结核性麻风病患者中均观察到IgE的多克隆激活，在结核病组中水平较高，这不支持麻风病性麻风病患者的选择性TH2激活。在这些患者中，IgG1和IgG3抗体也显示出最高的Spearman等级与细菌指数相关性（IgG1的rho = 0.748和P <0.001; IgG3的rho = 0.721和P <0.001）。因此，麻风病的进展与IgG1和IgG3反应的选择性增加有显着相关性。

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