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首页> 外文期刊>Infection and immunity >Salmonella typhi stimulation of human intestinal epithelial cells induces secretion of epithelial cell-derived interleukin-6.
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Salmonella typhi stimulation of human intestinal epithelial cells induces secretion of epithelial cell-derived interleukin-6.

机译：伤寒沙门氏菌刺激人肠上皮细胞可诱导上皮细胞衍生的白介素6分泌。

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Interleukin 6 (IL-6) is a multifunctional cytokine that has been shown to be associated with both systemic and tissue-specific responses within the host. Moreover, IL-6 is produced by both lymphoid and nonlymphoid cells and has been identified as a growth-inducing, growth-inhibiting, and differentiation-inducing factor for these cells. Recent studies of uropathogenic and upper respiratory pathogens have suggested that epithelial cell-derived IL-6 plays a role in mucosal host-parasite interactions. Since many mucosal enteric pathogens enter the host through the epithelial cells of the distal small intestine, a role for intestinal epithelial cell-derived IL-6 in the initial interaction between bacteria and host might also be predicted. However, no studies to date have determined whether the interaction of any bacteria with the epithelial cells that line the small intestine of the host can induce IL-6. To address this issue, we have established an in vitro model to evaluate the capacity of the gram-negative bacterium Salmonella typhi to induce IL-6 in the small intestine epithelial cell line Int407 and in other intestinal epithelial cell lines. The results demonstrate that both wild-type and live, attenuated S. typhi vaccine strains induce small and large intestine epithelial cells to secrete IL-6, and kinetic analysis suggests that IL-6 may be one of the earliest responses following adherence and invasion of enteric organisms. Thus, these studies suggest a physiologic role for epithelial cell-derived IL-6 in the initial interactions between host and bacterium in the small intestine.
机译：白介素6（IL-6）是一种多功能细胞因子，已被证明与宿主体内的全身和组织特异性反应均相关。此外，IL-6由淋巴样细胞和非淋巴样细胞两者产生，并且已被确定为这些细胞的生长诱导，生长抑制和分化诱导因子。尿毒症和上呼吸道病原体的最新研究表明，上皮细胞来源的IL-6在粘膜宿主-寄生虫相互作用中起作用。由于许多粘膜肠病原体通过远端小肠的上皮细胞进入宿主，因此也可以预测肠上皮细胞来源的IL-6在细菌与宿主之间的初始相互作用中的作用。但是，迄今为止，尚无研究确定任何细菌与位于宿主小肠周围的上皮细胞之间的相互作用是否可以诱导IL-6。为了解决这个问题，我们建立了一个体外模型来评估革兰氏阴性细菌伤寒沙门氏菌在小肠上皮细胞系Int407和其他肠上皮细胞系中诱导IL-6的能力。结果表明，野生型和活的减毒伤寒沙门氏菌疫苗株均可诱导大小肠小肠上皮细胞分泌IL-6，动力学分析表明，IL-6可能是粘连和侵袭后最早的反应之一。肠道生物。因此，这些研究表明上皮细胞来源的IL-6在小肠中宿主与细菌之间的初始相互作用中的生理作用。

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