• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Infection and immunity >Experimental Helicobacter pylori Infection Induces Antral Gastritis and Gastric Mucosa-Associated Lymphoid Tissue in Guinea Pigs
【24h】

Experimental Helicobacter pylori Infection Induces Antral Gastritis and Gastric Mucosa-Associated Lymphoid Tissue in Guinea Pigs

机译：实验性幽门螺杆菌感染在豚鼠中引起胃窦胃炎和胃粘膜相关淋巴组织

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Humans infected with Helicobacter pylori have abnormally low levels of the antioxidant vitamin C, which protects against the formation of carcinogenic nitrosamines, in gastric juice. Guinea pigs, like humans and nonhuman primates, have a dietary requirement for vitamin C. As such, these species have gastrointestinal vitamin C transport systems not found in other animals. We have developed and characterized a guinea pig model of chronic gastricH. pylori infection with the rodent-adapted Sydney strain of H. pylori. At 4 weeks postinfection, five of six animals of the infected group and zero of two animals of the control group were positive for H. pylori as determined by culture or PCR. At 15 weeks, six of six animals of the infected group and zero of two animals of the control group were positive. H. pylori-specific seroconversion was observed among infected animals. There were no histologic abnormalities in the gastric antra or fundi of control guinea pigs. In contrast, there was multifocal, mild to moderate lymphohistiocytic antral gastritis and formation of antral lymphoid follicles in H. pylori-infected animals. The lesion distribution in the gastric antra paralleled that observed in H. pylori-infected humans. The H. pylori-infected guinea pig should prove useful in modeling the interaction of helicobacter and vitamin C in gastric carcinogenesis.
机译：感染幽门螺杆菌的人的抗氧化剂维生素C含量异常低，可防止在胃液中形成致癌的亚硝胺。像人类和非人类灵长类动物一样，豚鼠也需要维生素C的饮食。因此，这些物种具有胃肠道中其他动物所没有的维生素C转运系统。我们已经开发并鉴定了慢性胃H豚鼠模型。适应啮齿动物的悉尼毒株 H感染幽门螺杆菌。幽门炎。感染后4周，感染组的六只动物中有五只，对照组的两只动物中有零只为 H阳性。幽门螺杆菌（通过培养或PCR测定）在第15周，感染组的六只动物中的六只为阳性，对照组的两只动物中的零只为阳性。 H。在感染的动物中观察到幽门螺旋菌特异性的血清转化。对照豚鼠的胃窦或胃底无组织学异常。相反，在 H中存在多灶，轻度至中度的淋巴组织细胞性胃炎并形成了窦性淋巴滤泡。幽门螺杆菌感染的动物胃窦的病变分布与在 H中观察到的平行。幽门螺杆菌感染的人 H。幽门螺杆菌感染的豚鼠应被证明可用于模拟幽门螺杆菌和维生素C在胃癌发生中的相互作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号