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首页> 外文期刊>Infection and immunity >Activation of Natural Killer Cells in Arthritis-Susceptible but Not Arthritis-Resistant Mouse Strains following Borrelia burgdorferi Infection
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Activation of Natural Killer Cells in Arthritis-Susceptible but Not Arthritis-Resistant Mouse Strains following Borrelia burgdorferi Infection

机译：伯氏疏螺旋体感染后对关节炎敏感但对关节炎没有抵抗力的小鼠品系中自然杀伤细胞的活化

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Infection of susceptible mouse strains with Borrelia burgdorferi, the agent of Lyme disease, results in the development of arthritis. Components of the innate immune system may be important mediators of this pathology. To investigate the potential role of NK cells in development of experimental Lyme arthritis, we examined their activation in vivo in both resistant and susceptible mouse strains. Following inoculation of B. burgdorferi into the footpad, lymph node NK cells from susceptible C3H/HeJ (C3H) mice produced more gamma interferon than NK cells from resistant DBA/2J mice. Lymph node cells from susceptible C3H and AKR mice also had increased ability to lyse YAC-1 target cells 2 days following infection. Antibody depletion of NK cells from susceptible mice, however, did not alter the development of arthritis following B. burgdorferi challenge. In addition, NK cell depletion had little effect on spirochete burden. Thus, there is a marked activation of NK cells in susceptible mouse strains following infection. Although NK cells are not absolutely required for arthritis, events occurring prior to NK cell activation might be important in mediating pathology in experimental Lyme disease.
机译：易感小鼠品系被莱姆病的病原体博氏疏螺旋体感染，导致了关节炎的发展。先天免疫系统的成分可能是这种病理的重要介体。为了研究NK细胞在实验莱姆关节炎发展中的潜在作用，我们研究了它们在抗性和易感小鼠品系中的体内激活作用。接种 B之后。在脚掌中，易感C3H / HeJ（C3H）小鼠的淋巴结NK细胞比抗性DBA / 2J小鼠的NK细胞产生更多的γ干扰素。感染后2天，来自易感C3H和AKR小鼠的淋巴结细胞也具有增加溶解YAC-1靶细胞的能力。然而，来自易感小鼠的NK细胞抗体耗竭并没有改变 B后关节炎的发展。 burgdorferi 挑战。此外，NK细胞的消耗对螺旋体负担几乎没有影响。因此，在感染后易感小鼠品系中NK细胞明显活化。尽管关节炎并非绝对需要NK细胞，但在NK细胞活化之前发生的事件对于介导实验莱姆病的病理可能很重要。

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