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首页> 外文期刊>Infection and immunity >Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism.
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Ecology of Candida albicans gut colonization: inhibition of Candida adhesion, colonization, and dissemination from the gastrointestinal tract by bacterial antagonism.

机译：白色念珠菌肠道定植的生态学：细菌拮抗作用抑制念珠菌的粘附，定植和从胃肠道传播。

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Antibiotic-treated and untreated Syrian hamsters were inoculated intragastrically with Candida albicans to determine whether C. albicans could opportunistically colonize the gastrointestinal tract and disseminate to visceral organs. Antibiotic treatment decreased the total population levels of the indigenous bacterial flora and predisposed hamsters to gastrointestinal overgrowth and subsequent systemic dissemination by C. albicans in 86% of the animals. Both control hamsters not given antibiotics and antibiotic-treated animals reconventionalized with an indigenous microflora showed significantly lower gut populations of C. albicans, and C. albicans organisms were cultured from the visceral organs of 0 and 10% of the animals, respectively. Conversely, non-antibiotic-treated hamsters inoculated repeatedly with C. albicans had high numbers of C. albicans in the gut, and viable C. albicans was recovered from the visceral organs of 53% of the animals. Examination of the mucosal surfaces from test and control animals indicated further that animals which contained a complex indigenous microflora had significantly lower numbers of C. albicans associated with their gut walls than did antibiotic-treated animals. The ability of C. albicans to associate with intestinal mucosal surfaces also was tested by an in vitro adhesion assay. The results indicate that the indigenous microflora reduced the mucosal association of C. albicans by forming a dense layer of bacteria in the mucus gel, out-competing yeast cells for adhesion sites, and producing inhibitor substances (possibly volatile fatty acids, secondary bile acids, or both) that reduced C. albicans adhesion. It is suggested, therefore, that the indigenous intestinal microflora suppresses C. albicans colonization and dissemination from the gut by inhibiting Candida-mucosal association and reducing C. albicans population levels in the gut.
机译：将经抗生素处理和未经处理的叙利亚仓鼠在胃内接种白色念珠菌，以确定白色念珠菌是否可以机会性地在胃肠道定居并扩散到内脏器官。抗生素治疗降低了本地细菌菌群的总种群水平，并使仓鼠易患胃肠道过度生长，并随后在86％的动物中由白色念珠菌全身传播。既没有给予抗生素的对照仓鼠，又有经过本地微生物群落重新常规化处理的抗生素处理动物，其肠道菌群均显着降低，白色念珠菌的肠道菌群分别来自0％和10％动物的内脏器官。相反，反复接种白色念珠菌的未经抗生素处理的仓鼠的肠道中白色念珠菌的数量很高，并且从53％的动物的内脏器官中回收到了可行的白色念珠菌。从试验和对照动物的粘膜表面检查进一步表明，与抗生素治疗的动物相比，含有复杂的原生菌群的动物与肠壁相关的白色念珠菌数量明显减少。白色念珠菌与肠粘膜表面缔合的能力也通过体外粘附测定法进行了测试。结果表明，土著微生物区系通过在粘液凝胶中形成致密的细菌层，使酵母细胞竞争粘附位点并产生抑制剂物质（可能是挥发性脂肪酸，仲胆汁酸，或两者皆有），降低白色念珠菌的黏附力。因此，建议通过抑制念珠菌-粘膜结合并降低肠道中的白色念珠菌种群水平，土著肠道菌群抑制白色念珠菌的定植和从肠道的扩散。

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