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首页> 外文期刊>Infection and immunity >Susceptibilities of macrophage populations to infection in vitro by Leishmania donovani.
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Susceptibilities of macrophage populations to infection in vitro by Leishmania donovani.

机译：巨噬细胞种群对体外利什曼原虫感染的敏感性。

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Many studies have demonstrated differences in the resistance of strains of mice to infection by Leishmania donovani, Salmonella typhimurium, and Mycobacterium bovis BCG; this resistance/susceptibility phenotype seems to be controlled by a single gene. The present study investigated the susceptibility of liver, lung, peritoneal, and spleen macrophages to infection by L. donovani promastigotes in vitro; the objective was to determine if the susceptibility of animals was expressed by their macrophages when infected in vitro. This study indicated that the Lsh phenotype was only expressed by liver macrophages. The liver macrophages of the susceptible C57BL/6J strain were significantly more phagocytic than those of the resistant C57L/J strain; infection affected the phagocytic activity of the macrophage population. These results indicated that only liver macrophages can express the Lsh gene. Recognition of expression is in part due to its effect on the phagocytic activity of the macrophages.
机译：许多研究表明，小鼠品系对利什曼原虫，鼠伤寒沙门氏菌和牛分枝杆菌BCG感染的抗性存在差异。这种抗性/敏感性表型似乎受单个基因控制。本研究调查了肝，肺，腹膜和脾巨噬细胞在体外感染多诺氏乳杆菌前体的易感性。目的是确定动物在体外感染时是否通过巨噬细胞表达其敏感性。这项研究表明，Lsh表型仅由肝巨噬细胞表达。易感的C57BL / 6J菌株的肝巨噬细胞吞噬能力明显高于耐药的C57L / J菌株。感染影响巨噬细胞种群的吞噬活性。这些结果表明仅肝巨噬细胞可以表达Lsh基因。表达的识别部分是由于其对巨噬细胞吞噬活性的影响。

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