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首页> 外文期刊>Infection and immunity >Roles of CD4- and CD8-bearing T lymphocytes in the immune response to the erythrocytic stages of Plasmodium chabaudi.
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Roles of CD4- and CD8-bearing T lymphocytes in the immune response to the erythrocytic stages of Plasmodium chabaudi.

机译：携带CD4和CD8的T淋巴细胞在Chabaudi疟原虫红细胞阶段免疫应答中的作用。

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摘要

The possible role of CD4- and CD8-bearing T lymphocytes in parasite clearance in vivo was investigated, using Plasmodium chabaudi in C57BL/6 mice as a model. Monoclonal antibodies specific for the CD4 and CD8 molecules were administered in vivo to deplete selectively the appropriate subset of T cells. The efficacy of depletion was ascertained by flow cytometry and functional studies. These mice were then infected with P. chabaudi, and the course of infection was followed. The control groups had maximum parasitemias of approximately 30% 10 days after infection, and the infection was cleared within 27 days. Mice without CD4+ cells had significantly higher parasitemias which they were unable to reduce below 20% for the duration of the experiment. Mice without CD8 cells had slightly higher parasitemias which were cleared after 34 days. Because of the possibility that CD8+ cells alone could not be activated in the absence of growth factors, exogenous interleukin-2 was administered to the mice depleted of CD4 cells. This did not significantly affect parasitemias, and the mice were still unable to clear their infections. The data suggest that CD4+ T cells play a crucial role in the protective immune response to the erythrocytic stages of P. chabaudi.
机译：使用C57BL / 6小鼠的chabaudi疟原虫作为模型，研究了携带CD4和CD8的T淋巴细胞在体内寄生虫清除中的可能作用。在体内施用对CD4和CD8分子具有特异性的单克隆抗体，以选择性地消耗T细胞的适当亚群。通过流式细胞术和功能研究确定衰竭的功效。然后将这些小鼠感染chapaudi P. chabaudi，并遵循感染过程。对照组在感染后10天有最大的寄生虫病，大约30％，并且感染在27天内被清除。没有CD4 +细胞的小鼠具有更高的寄生虫性，因此在整个实验过程中它们无法降低至20％以下。没有CD8细胞的小鼠寄生虫病稍高，在34天后被清除。由于缺少生长因子时无法单独激活CD8 +细胞的可能性，因此向耗竭CD4细胞的小鼠施用了外源性白介素2。这并没有显着影响寄生虫病，小鼠仍然无法清除感染。数据表明，CD4 + T细胞在对chabaudi红细胞阶段的保护性免疫反应中起着至关重要的作用。

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