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首页> 外文期刊>Infection and immunity >Autoantibodies to the mitotic spindle apparatus in Mycoplasma pneumoniae disease.
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Autoantibodies to the mitotic spindle apparatus in Mycoplasma pneumoniae disease.

机译：肺炎支原体病中有丝分裂纺锤体自身抗体。

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摘要

Antibodies to the mitotic spindle apparatus (MS) have been detected in only a very few patient sera studied for antinuclear antibodies by routine screening (G. A. McCarty, D. W. Velencia, and M. J. Fritzler, J. Rheumatol. 11:213-218, 1984). We found anti-MS antibodies to be quite common in sera from patients with Mycoplasma pneumoniae, especially in those who developed cold agglutinins (71%). Absorption experiments indicated that the formation of anti-MS antibodies is not triggered by epitopes on the M. pneumoniae surface. These antibodies were distinct from cold agglutinins, antibrain antibodies, and smooth-muscle antibodies. All patients previously reported to harbor anti-MS had clinical features compatible with a diagnosis of systemic lupus erythematosus, rheumatoid arthritis, or an evolving connective-tissue disorder. Such systemic disorders might develop in a small proportion of patients who have had M. pneumoniae illness.
机译：通过常规筛查仅在极少数研究抗核抗体的患者血清中检测到有丝分裂纺锤体抗体（MS）（G. A. McCarty，D. W. Velencia，and M. J. Fritzler，J. Rheumatol。11：213-218，1984）。我们发现抗MS抗体在肺炎支原体患者的血清中非常普遍，特别是在发生冷凝集素的患者中（71％）。吸收实验表明抗MS抗体的形成不是由肺炎支原体表面上的表位触发的。这些抗体不同于冷凝集素，抗脑抗体和平滑肌抗体。先前报道所有具有抗MS的患者均具有与系统性红斑狼疮，类风湿性关节炎或发展中的结缔组织疾病的诊断兼容的临床特征。少数患有肺炎支原体疾病的患者可能会出现这种全身性疾病。

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