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首页> 外文期刊>Infection and immunity >Cathepsin D-like activity in neutrophils and monocytes.
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Cathepsin D-like activity in neutrophils and monocytes.

机译：中性粒细胞和单核细胞中组织蛋白酶D样活性。

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摘要

Monocytes-macrophages and polymorphonuclear leukocytes contain an acid proteolytic enzyme that cleaves tritiated hemoglobin. The monocyte-macrophage-derived enzymatic activity was completely inhibited by pepstatin A, a property of cathepsin D. Monocyte-derived macrophages developed detectable cathepsin D-like activity after 5 days in culture, and this activity coincided with the appearance of other known indicators of macrophage maturation. The cathepsin D activity further increased significantly with time after day 5 of culture. The proteinase activity extracted from neutrophils was only partially inhibitable by pepstatin A, which indicates that this activity is contributed by more than one proteolytic enzyme, including cathepsin D. Cathepsin D activity demonstrated in neutrophils and macrophages may be an important marker of phagocyte function.
机译：单核细胞巨噬细胞和多形核白细胞含有一种能切割pro化血红蛋白的酸性蛋白水解酶。组织蛋白酶D的一种性质pepstatin A完全抑制了单核细胞巨噬细胞衍生的酶活性。培养5天后，单核细胞衍生的巨噬细胞培养出可检测到的组织蛋白酶D样活性，该活性与其他已知指标的出现相吻合。巨噬细胞成熟。组织蛋白酶D活性在培养的第5天后随时间进一步显着增加。从胃中性粒细胞提取的蛋白酶活性仅被胃蛋白酶抑制素A部分抑制，这表明该活性是由一种以上的蛋白水解酶（包括组织蛋白酶D）贡献的。中性粒细胞和巨噬细胞中显示的组织蛋白酶D活性可能是吞噬细胞功能的重要标志。

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