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首页> 外文期刊>Infection and immunity >Attacin, an antibacterial protein from Hyalophora cecropia, inhibits synthesis of outer membrane proteins in Escherichia coli by interfering with omp gene transcription.
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Attacin, an antibacterial protein from Hyalophora cecropia, inhibits synthesis of outer membrane proteins in Escherichia coli by interfering with omp gene transcription.

机译：Attacin是一种来自头孢霉菌的抗菌蛋白，它通过干扰omp基因转录来抑制大肠杆菌中外膜蛋白的合成。

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摘要

Attacins are antibacterial proteins synthesized by pupae of the giant silk moth, Hyalophora cecropia, in response to a bacterial infection. In this report we show that the previously described, attacin-induced alteration in the structure and the permeability of the outer membrane of Escherichia coli is associated with a specific inhibition of the synthesis of several outer membrane proteins, including OmpC, OmpF, OmpA, and LamB. The inhibition is expressed as a reduction in the steady-state mRNA levels and is at least in part the results of a block in transcription of the corresponding genes. Transcription directed by the promoter of ompR, the positive regulator of ompC and ompF expression in response to environmental conditions, is also affected by attacin. The effects on mutant strains show that the primary activity of attacin is not mediated by the ompR-envZ regulatory system. Instead our data suggest the existence in E. coli of a previously unknown system for the transcriptional regulation of a large set of outer membrane proteins previously not known to be coordinately regulated. We propose that the activity of attacin is directed towards this system.
机译：Attacins是由巨大的蚕蛾p（Hyalophora cecropia）的ae响应细菌感染而合成的抗菌蛋白。在本报告中，我们显示了先前描述的，阿塔霉素诱导的大肠杆菌外膜结构和通透性的改变与几种外膜蛋白（包括OmpC，OmpF，OmpA和羊肉。抑制表示为稳态mRNA水平的降低，并且至少部分是相应基因转录阻断的结果。由ompR的启动子（ompC和ompF表达的正向调节剂，响应于环境条件）指导的转录也受阿塔霉素的影响。对突变菌株的影响表明，连接素的主要活性不受ompR-envZ调节系统的介导。相反，我们的数据表明在大肠杆菌中存在一个以前未知的系统，该系统用于转录调节以前未知的大量外膜蛋白。我们建议，连接素的活性是针对该系统的。

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