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首页> 外文期刊>Infection and immunity >Binding of host collectins to the pathogenic yeast Cryptococcus neoformans: human surfactant protein D acts as an agglutinin for acapsular yeast cells.
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Binding of host collectins to the pathogenic yeast Cryptococcus neoformans: human surfactant protein D acts as an agglutinin for acapsular yeast cells.

机译：宿主收集素与致病性酵母新隐球菌的结合：人表面活性剂蛋白D充当荚膜酵母细胞的凝集素。

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摘要

Cryptococcus neoformans is an opportunistic pathogen in AIDS patients causing disseminated disease and lethal meningitis after inhalation of acapsular or sparsely encapsulated yeast cells. In this study we have investigated whether a recently described family of primitive opsonins, termed collectins, contribute to innate resistance against C. neoformans. The pulmonary surfactant proteins SP-A and SP-D as well as the serum collectins mannose-binding protein and CL-43 bound in a calcium-dependent manner to acapsular C. neoformans in vitro. Binding was concentration dependent and abolished by competition with defined mono- and oligosaccharides. In contrast, no binding of the collectins was observed with the encapsulated form of the yeast. Furthermore, binding of purified collectin SP-D, but not SP-A, mannose-binding protein, or CL-43, led to a concentration-dependent agglutination of acapsular C. neoformans. These data indicate that collectins recognize carbohydrate structures in the cell wall of an initial infectious form of C. neoformans and may play a role in early antifungal defenses in the lung.
机译：新型隐球菌是艾滋病患者中的机会病原体，在吸入荚膜或稀疏包囊的酵母细胞后会引起传播性疾病和致死性脑膜炎。在这项研究中，我们调查了最近描述的原始调理素家族（称为collectin）是否对天生梭状芽胞杆菌具有抗性。肺表面活性剂蛋白SP-A和SP-D以及血清collectins甘露糖结合蛋白和CL-43以钙依赖的方式在体外与荚膜新孢子虫结合。结合是浓度依赖性的，并且通过与确定的单糖和寡糖竞争而废除。相反，用酵母的包囊形式未观察到collectin的结合。此外，纯化的collectin SP-D的结合而不是SP-A，甘露糖结合蛋白或CL-43的结合导致荚膜梭状芽孢杆菌的浓度依赖性凝集。这些数据表明，collectin可识别新感染梭状芽胞杆菌的初始感染形式的细胞壁中的碳水化合物结构，并且可能在肺部的早期抗真菌防御中发挥作用。

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