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首页> 外文期刊>Infection and immunity >Transforming growth factor beta is protective in host resistance against Listeria monocytogenes infection in mice.
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Transforming growth factor beta is protective in host resistance against Listeria monocytogenes infection in mice.

机译：转化生长因子β在宿主抵抗小鼠单核细胞增多性李斯特菌感染中具有保护作用。

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The role of transforming growth factor beta (TGF-beta) in host resistance against Listeria monocytogenes infection was studied with mice. The constitutive expression of TGF-beta 1 mRNA was observed in the spleens and livers of mice before and after infection. Injecting the mice with anti-TGF-beta 1 peptide serum resulted in diminished antilisterial resistance, whereas the administration of human platelet-derived TGF-beta 1 enhanced the resistance. Moreover, mice were protected against lethal infection when treated with TGF-beta 1. These results suggest the TGF-beta 1 might be involved in antilisterial resistance. On the other hand, injecting the mice with TGF-beta 1 resulted in a decrease in the titers of endogenous gamma interferon, tumor necrosis factor alpha, and interleukin-6, which are crucial in antilisterial resistance, in sera and in extracts of spleen and liver. Thus, a complicated mechanism might be involved in the role of TGF-beta 1 in host resistance against L. monocytogenes infection.
机译：用小鼠研究了转化生长因子β（TGF-β）在宿主抗李斯特菌感染中的作用。在感染前后，小鼠的脾脏和肝脏中均观察到TGF-β1mRNA的组成型表达。向小鼠注射抗TGF-β1肽血清导致抗李斯特菌耐药性降低，而给予人血小板衍生的TGF-β1则增强了耐药性。此外，当用TGF-beta 1治疗时，可以保护小鼠免于致命感染。这些结果表明，TGF-beta 1可能与抗李斯特菌有关。另一方面，给小鼠注射TGF-β1会导致血清，脾脏和脾脏提取物中内源性γ干扰素，肿瘤坏死因子α和白介素-6的效价降低，这对抗李斯特菌耐药性至关重要肝。因此，TGF-beta 1在抗单核细胞增生李斯特菌感染的宿主抗性中的作用可能涉及复杂的机制。

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