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首页> 外文期刊>Infection and immunity >Distinct Characteristics of Resistance toBorrelia burgdorferi-Induced Arthritis in C57BL/6N Mice
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Distinct Characteristics of Resistance toBorrelia burgdorferi-Induced Arthritis in C57BL/6N Mice

机译：C57BL / 6N小鼠对伯氏疏螺旋体诱导的关节炎的抵抗力的不同特征

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Studies of mice infected with Borrelia burgdorferi have indicated that the severity of arthritis is influenced by the genetic composition of the host: the C3H mouse develops severe arthritis while BALB/c and C57BL/6 mice develop mild arthritis. In this study, the effects of increasing infectious dose on the severity of arthritis were determined in these three mouse strains. C3H/He mice developed severe arthritis at all infectious doses, with 100% infection requiring 200 spirochetes. In BALB/cAnN mice, arthritis severity was dependent on infectious dose; symptoms were mild with infection by 200 B. burgdorferi and progressively more severe with increasing infectious dose. Infection of BALB/cAnN mice with 2 × 104 B. burgdorferi resulted in arthritis with severity identical to that in C3H/He mice. Spirochete levels in rear ankle joints of C3H/HeJ and C3H/HeN mice were relatively high, as detected by PCR, and did not increase with infectious dose. Spirochete levels in joints from BALB/cAnN mice increased with increasing infectious dose to levels found in severely arthritic C3H/He mice. Thus, resistance to severe arthritis in BALB/cAnN mice was conditional: it could be overcome by high infectious dose and the arthritis became severe when high levels of B. burgdorferi were present in joints. A unique response to increasing infectious dose was seen in C57BL/6N mice, which displayed mild to moderate arthritis at all doses of B. burgdorferi tested, up to 2 × 105. At all infectious doses, the levels of spirochetes in ankle joints of C57BL/6N mice were high, equivalent to those found in the severely arthritic C3H/He mice. The arthritis observed in infected (C57BL/6N × C3H/HeN)F1 mice was of severity intermediate between those of the two parental strains. The finding that resistance to severe arthritis in C57BL/6N mice could not be overcome by high infectious doses and was independent of spirochete levels in joints suggested that it was mediated by a distinct mechanism from that operating in BALB/cAnN mice.
机译：对感染伯氏疏螺旋体的小鼠的研究表明，关节炎的严重程度受宿主基因组成的影响：C3H小鼠发展为严重的关节炎，而BALB / c和C57BL / 6小鼠则发展为轻度关节炎。在这项研究中，确定了这三种小鼠品系中感染剂量增加对关节炎严重程度的影响。 C3H / He小鼠在所有感染剂量下均患有严重的关节炎，其中100％的感染需要200个螺旋体。在BALB / cAnN小鼠中，关节炎的严重程度取决于感染剂量。症状轻微，被200 B感染。 burgdorferi ，并随着感染剂量的增加而逐渐加重。 BALB / cAnN小鼠感染2×10 4 B。 burgdorferi 导致的关节炎严重程度与C3H / He小鼠相同。通过PCR检测，C3H / HeJ和C3H / HeN小鼠后踝关节中的Spirochete水平较高，并且不随感染剂量增加。 BALB / cAnN小鼠关节中的Spirochete水平随感染剂量的增加而增加，达到严重关节炎C3H / He小鼠中的水平。因此，在BALB / cAnN小鼠中对严重关节炎的抗性是有条件的：可以通过高感染剂量来克服，并且当高水平的 B时，关节炎变得严重。关节中有burgdorferi 。在C57BL / 6N小鼠中观察到了对感染剂量增加的独特反应，该小鼠在所有剂量的B下均表现出轻度至中度关节炎。 burgdorferi 经过测试，最多2×10 5 。在所有感染剂量下，C57BL / 6N小鼠的踝关节中螺旋体的水平都很高，与严重关节炎的C3H / He小鼠中的水平相当。在感染的（C57BL / 6N×C3H / HeN）F 1 小鼠中观察到的关节炎的严重程度介于两种亲本菌株之间。高感染剂量无法克服C57BL / 6N小鼠对严重关节炎的抵抗力，并且不受关节中螺孢子水平的影响，这一发现表明，它是由与BALB / cAnN小鼠不同的机制介导的。

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