Objective:Taking collagen-induced arthritis(CIA) as experimental subject,make comparative study on species to quest for the moderate method of making the CIA mice model. Methods:CIA model was induced by chicken type Ⅱcollagen (CⅡ) in DBA/1 and C57BL/6 mice. The joints of the mice were observed for clinical manifestation and clinical score of swelling. Results:Paw-swelling onset was on day 31 after the first immunization in DBA/1 mice. Clinical score for swelling of the paws reached peak on day 39 after the first immunization. As time went on , the acute inflammation of paws decreased. By using an improved method, paw-swelling onset was on day 21 after the first immunization in C57BL/6 mice. Conclusion:The DBA/1 mice were recommend for CIA animal model.%目的：对胶原诱导性关节炎(collagen-induced arthritis，CIA)在不同品系小鼠(DBA/1小鼠和C57BL/6小鼠)的发病情况进行比较研究，以期寻找出一种适合制备CIA模型的小鼠品系。方法：用鸡Ⅱ型胶原(typeⅡcollagen， CⅡ)乳剂分别免疫DBA/1小鼠和C57BL/6小鼠诱导CIA，进行关节外观的观察及关节炎临床评分。结果：免疫后第31天， DBA/1小鼠出现关节红肿，关节炎临床评分升高，在第39天达到高峰。随着时间的推移，小鼠关节红肿等急性炎症现象有所减退。用改进方法免疫的C57BL/6小鼠于第21天开始出现关节红肿、临床评分升高现象。结论：在制备CIA模型时建议首选DBA/1小鼠。
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