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首页> 外文期刊>Infection and immunity >Pathways for Potentiation of Immunogenicity during Adjuvant-Assisted Immunizations with Plasmodium falciparumMajor Merozoite Surface Protein 1
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Pathways for Potentiation of Immunogenicity during Adjuvant-Assisted Immunizations with Plasmodium falciparumMajor Merozoite Surface Protein 1

机译：恶性疟原虫主要辅助裂殖子表面蛋白1在辅助辅助免疫过程中增强免疫原性的途径

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Vaccine adjuvants exert critical and unique influences on the quality of immune responses induced during active immunizations. We investigated the mechanisms of action of immunological adjuvants in terms of their requirements for cytokine-mediated pathways for adjuvanticity. Antibody responses potentiated by several adjuvants to a Plasmodium falciparum MSP1-19 (C-terminal 19-kDa processing fragment of MSP1) vaccine were studied in gamma interferon (IFN-γ) or interleukin (IL-4) knockout mice. The levels of anti-MSP1-19 antibodies and the induction of Th1- and Th2-type antibodies were analyzed. Results revealed a spectrum of requirements for cytokine-mediated pathways in the potentiation of immunogenicity, and such requirements were influenced by interactions among individual components of the adjuvant formulations. One adjuvant strictly depended on IFN-γ to induce appreciable levels of anti-MSP1-19 antibodies, while some formulations required IFN-γ only for the induction of Th1-type antibodies. Other formulations induced exclusively Th2-type antibodies and were not affected by IFN-γ knockout. There were three patterns of requirements for IL-4 by various adjuvants in the induction of Th2-type anti-MSP1-19 antibodies. Moreover, the induction of Th1-type anti-MSP1-19 antibodies by adjuvants showed two distinct patterns of regulation by IL-4. The utilization of an IL-4 regulated pathway(s) for the induction of Th2-type antibodies by the same adjuvant differed between mouse strains, suggesting that animal species variability in responses to vaccine adjuvants may be due, at least in part, to differences in the utilization of immune system pathways by an adjuvant among animal hosts.
机译：疫苗佐剂对主动免疫过程中诱导的免疫反应质量产生关键而独特的影响。我们根据细胞因子介导的佐剂途径对免疫佐剂的作用机制进行了研究。在γ干扰素（IFN-γ）或白介素（IL-4）中研究了几种佐剂对恶性疟原虫MSP1-19（MSP1的C末端19-kDa加工片段）疫苗增强的抗体应答。剔除小鼠。分析了抗MSP1-19抗体的水平以及Th1-和Th2-型抗体的诱导。结果揭示了在免疫原性增强中对细胞因子介导的途径的要求范围，并且这些要求受到佐剂制剂的各个组分之间相互作用的影响。一种佐剂严格依赖于IFN-γ来诱导一定水平的抗MSP1-19抗体，而某些制剂仅需要IFN-γ来诱导Th1型抗体。其他制剂仅诱导Th2型抗体，不受IFN-γ敲除的影响。在诱导Th2型抗MSP1-19抗体中，各种佐剂对IL-4的需求存在三种模式。此外，佐剂对Th1型抗MSP1-19抗体的诱导显示出IL-4调节的两种不同模式。在小鼠品系之间，IL-4调节途径通过同一种佐剂诱导Th2型抗体的诱导方法有所不同，这表明动物物种对疫苗佐剂的反应差异可能至少部分是由于差异动物宿主中佐剂在利用免疫系统途径中的作用。

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