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首页> 外文期刊>Infection and immunity >Effect of Influenza A Virus Infection on Nasopharyngeal Colonization and Otitis Media Induced by Transparent or Opaque Phenotype Variants of Streptococcus pneumoniae in the Chinchilla Model
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Effect of Influenza A Virus Infection on Nasopharyngeal Colonization and Otitis Media Induced by Transparent or Opaque Phenotype Variants of Streptococcus pneumoniae in the Chinchilla Model

机译：A型流感病毒感染对龙猫模型中透明或不透明表型变异的肺炎链球菌诱导的鼻咽定植和中耳炎的影响

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Phase variation in the colonial opacity of Streptococcus pneumoniae has been implicated as a factor in bacterial adherence, colonization, and invasion in the pathogenesis of pneumococcal disease. Additionally, the synergistic effects of influenza A virus and S. pneumoniae in the development of otitis media (OM) have been reported. This study examined the ability of opaque or transparent S. pneumoniae from the same strain in combination with an antecedent influenza A virus infection to colonize the nasopharynx and invade the middle ear in the chinchilla model. Our data indicated that there was no significant difference in the level of nasopharyngeal colonization and induction of OM between the opaque and transparent variants unless there was a prior challenge with influenza A virus. Subsequent to influenza A virus infection, there was a significant difference between the variants in the ability to colonize and persist in the nasopharynx and middle ear. The concentrations of the opaque variant in nasopharyngeal-lavage samples and middle-ear fluid remained consistently higher than those of the transparent variant for 10 days postinoculation. Data from this study indicate that the effects of influenza A virus on the pathogenesis of experimental S. pneumoniae-induced OM differ depending on the opacity phenotype involved.
机译：肺炎链球菌的菌落混浊的相变被认为是肺炎球菌病发病机理中细菌粘附，定植和侵袭的一个因素。此外，甲型流感病毒和 S的协同作用。肺炎在中耳炎（OM）发展中已有报道。这项研究检查了不透明或透明 S的能力。来自同一菌株的肺炎与先前的A型流感病毒感染相结合，从而在黄鼠模型中定居于鼻咽并侵袭中耳。我们的数据表明，除非事先用甲型流感病毒攻击，否则不透明变体和透明变体之间的鼻咽定植和OM诱导水平没有显着差异。甲型流感病毒感染后，这些变体之间在鼻咽和中耳的定居和持续能力存在显着差异。接种后10天，鼻咽灌洗液样品和中耳液中的不透明变体浓度始终高于透明变体。这项研究的数据表明，甲型流感病毒对实验性 S发病机理的影响。肺炎诱导的OM取决于所涉及的不透明度表型。

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