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首页> 外文期刊>Infection and immunity >Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas.
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Experimental otitis media after nasal inoculation of Streptococcus pneumoniae and influenza A virus in chinchillas.

机译：经鼻接种龙猫的肺炎链球菌和甲型流感病毒后，实验性中耳炎。

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摘要

Otitis media developed in 67% of chinchillas inoculated intranasally with type 7 Streptococcus pneumoniae and influenza A virus. Only 4% of chinchillas inoculated with influenza alone and 21% of chinchillas inoculated with S. pneumoniae alone developed otitis media. Among the chinchillas that developed otitis media after inoculation with both pneumococcus and influenza, 73% of the affected ears contained effusion, and 27% of the affected ears showed tympanic membrane inflammation without middle ear effusion obtained on paracentesis. Although a majority of the ears with effusion yielded S. pneumoniae on culture, one-third of the effusions were sterile for aerobic bacteria. This model resembles conditions accompanying otitis media in humans and suggests that respiratory viral infection contributes significantly to the pathogenesis of acute otitis media.
机译：鼻内接种7型肺炎链球菌和A型流感病毒后，在67％的龙猫中出现了中耳炎。仅4％的龙猫单独接种流感病毒，而21％的龙猫单独接种肺炎链球菌会发展为中耳炎。在肺炎球菌和流感疫苗接种后均发展为中耳炎的龙猫中，有73％的患病耳朵含有积液，而有27％的患病耳朵表现为鼓膜炎症，而穿刺穿刺未获得中耳积液。尽管大多数有渗出液的耳朵在培养时产生了肺炎链球菌，但其中有三分之一的渗出液对需氧菌是无菌的。该模型类似于人类中耳炎伴随的疾病，并表明呼吸道病毒感染在急性中耳炎的发病机理中起重要作用。

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