Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance

Alexandra van Remoortere; Govert J. van Dam; Cornelis H. Hokke; Dirk H. van den Eijnden; Irma van Die; AndréM. Deelder

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Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance

机译：表面等离子共振确定的血吸虫感染个体血清中定义的糖基抗原决定簇的免疫球蛋白M（IgM）和IgG抗体的概况

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We report here that sera of children and adults infected withSchistosoma mansoni, S. haematobium, or S. japonicum contain antibodies against GalNAcβ1-4(Fucα1-2Fucα1-3)GlcNAc (LDN-DF) and to a lesser extent to Galβ1-4(Fucα1-3)GlcNAc (Lewisx) and GalNAcβ1-4GlcNAc (LDN). Surface plasmon resonance (SPR) spectroscopy was used to monitor the presence of serum antibodies to neoglycoconjugates containing these carbohydrate epitopes and to define the immunoglobulin M (IgM) and IgG subclass distribution of the antibodies. The serum levels of antibodies to LDN-DF are high related to LDN and Lewisx for all examined groups ofSchistosoma-infected individuals. A higher antibody response to the LDN-DF epitope was found in sera of infected children than in sera of infected adults regardless of the schistosome species. With respect to the subclasses, we found surprisingly that individuals infected with S. japonicum have predominantly IgG antibodies, while individuals infected with S. mansonimainly show an IgM response; high levels of both isotypes were measured in sera of individuals infected with S. haematobium. These data provide new insights in the human humoral immune response to schistosome-derived glycans.

机译：我们在这里报告感染曼氏血吸虫，血吸虫链球菌或 S的儿童和成人的血清。 japonicum 含有针对GalNAcβ1-4（Fucα1-2Fucα1-3）GlcNAc（LDN-DF）的抗体，而针对Galβ1-4（Fucα1-3）GlcNAc（Lewis x ）的抗体含量较低和GalNAcβ1-4GlcNAc（LDN）。表面等离子体共振（SPR）光谱用于监测针对包含这些糖表位的新糖缀合物的血清抗体的存在，并定义抗体的免疫球蛋白M（IgM）和IgG亚类分布。在所有检测到的血吸虫感染个体中，LDN-DF抗体的血清水平与LDN和Lewis x 相关。无论血吸虫的种类如何，在受感染儿童的血清中发现的对LDN-DF表位的抗体应答均高于在受感染成人的血清中。关于子类，我们惊讶地发现感染了 S的个体。 japonicum 主要具有IgG抗体，而感染了 S的个体。 mansoni 主要表现为IgM反应;在感染 S的个体的血清中检测到两种同种型的高水平。血液。这些数据为人类对血吸虫来源的聚糖的体液免疫反应提供了新的见解。 展开▼

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《Infection and immunity》 |2001年第4期|共6页

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Alexandra van Remoortere; Govert J. van Dam; Cornelis H. Hokke; Dirk H. van den Eijnden; Irma van Die; AndréM. Deelder;
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1. Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance [J] . Alexandra van Remoortere, Govert J. van Dam, Cornelis H. Hokke, Infection and immunity . 2001,第4期

机译：表面等离子共振确定的血吸虫感染个体血清中定义的糖基抗原决定簇的免疫球蛋白M（IgM）和IgG抗体的概况

2. Reverse Enzyme-Linked Immunosorbent Assay Using Monoclonal Antibodies against SAG1-Related Sequence, SAG2A, and p97 Antigens from Toxoplasma gondii To Detect Specific Immunoglobulin G (IgG), IgM, and IgA Antibodies in Human Sera [J] . Fernando R. Carvalho, Deise A. O. Silva, Jair P. Cunha-Júnior, Clinical and vaccine immunology: CVI . 2008,第8期

机译：反向酶联免疫吸附测定，使用针对弓形虫SAG1相关序列，SAG2A和p97抗原的单克隆抗体检测人血清中的特异性免疫球蛋白G（IgG），IgM和IgA抗体

3. High throughput surface plasmon resonance imaging method for clinical detection of presence and strength of binding of IgM, IgG and IgA antibodies against SARS-CoV-2 during CoViD-19 infection [J] . Richard B.M. Schasfoort, Jos van Weperen, Margot van Amsterdam, MethodsX . 2021,第a期

机译：高通量表面等离子体谐振成像方法，用于临床检测IgM，IgG和IgA抗体结合的存在和强度，Covid-19感染期间SARS-COV-2的结合

4. IgG SUBCLASS ANTIBODIES IN TRANSPLANT RECIPIENT SERA: AN IgG SUBCLASS SPECIFIC ASSAY TO DETERMINE THE "GOOD AND BAD" IgG IMMUNOGLOBULINS [C] . J Cicciarelli, N Kasahara, B. Pitpitan, Clinical Histocompatibility Workshop. . 2009

机译：移植受体血清中的IgG亚类抗体：一种IgG亚类特异性测定以确定“良好和坏”IgG免疫球蛋白

5. Surface Plasmon Resonance Studies of the Specific Interactions of Hexamer Peptide Ligands with Human Immunoglobulin G. [D] . Islam, Nafisa. 2013

机译：六聚体肽配体与人免疫球蛋白G特异性相互作用的表面等离子体共振研究。

6. Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance [O] . Alexandra van Remoortere, Govert J. van Dam, Cornelis H. Hokke, 2001

机译：通过表面等离子共振确定的血吸虫感染个体血清中定义的糖基抗原决定簇的免疫球蛋白M（IgM）和IgG抗体的概况

7. Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance [O] . van Remoortere, Alexandra, van Dam, Govert J., Hokke, Cornelis H., 2001

机译：通过表面等离子共振确定的血吸虫感染个体血清中定义的糖基抗原决定簇的免疫球蛋白M（IgM）和IgG抗体的概况

8. Indirect Immunoglobulin G (IgG) and IgM Enzyme-Linked Immunosorbent Assays (ELISAs) and IgM Capture ELISA for Detection of Antibodies to Lipopolysaccharide in Adult Typhoid Fever Patients in Pakistan. [R] . Sippel, J., Bukhtiari, N., Awan, M. B., 1989

机译：间接免疫球蛋白G（IgG）和Igm酶联免疫吸附试验（ELIsas）和Igm捕获ELIsa检测巴基斯坦成年伤寒患者脂多糖抗体。

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Profiles of Immunoglobulin M (IgM) and IgG Antibodies against Defined Carbohydrate Epitopes in Sera of Schistosoma-Infected Individuals Determined by Surface Plasmon Resonance

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