Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection

Charlotte Larsson; Jan Holmgren; Gunnar Lindahl; Charlotta Bergquist

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Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection

机译：B组链球菌蛋白肋骨和霍乱毒素B亚基对小鼠的鼻内免疫可预防致命感染。

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Intranasal immunization of mice with Rib, a cell surface protein of group B streptococcus (GBS), conjugated to or simply coadministered with the recombinant cholera toxin B subunit, induces systemic immunoglobulin G (IgG) and local IgA antibody responses and confers protection against lethal GBS infection. These findings have implications for the development of a human GBS vaccine.

机译：与重组霍乱毒素B亚基缀合或简单联合使用的Rib（B组链球菌（GBS）组的细胞表面蛋白）对小鼠进行鼻内免疫，可诱导全身免疫球蛋白G（IgG）和局部IgA抗体应答，并提供针对致命GBS的保护感染。这些发现对人GBS疫苗的开发有影响。

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《Infection and immunity》 |2004年第2期|共4页
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Charlotte Larsson; Jan Holmgren; Gunnar Lindahl; Charlotta Bergquist;
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中图分类医学免疫学;
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1. Intranasal Immunization with the Cholera Toxin B Subunit-Pneumococcal Surface Antigen A Fusion Protein Induces Protection against Colonization with Streptococcus pneumoniae and Has Negligible Impact on the Nasopharyngeal and Oral Microbiota of Mice [J] . F. C. Pimenta, E. N. Miyaji, A. P. M. Arêas, Infection and immunity . 2006,第8期

机译：霍乱毒素B亚基-肺炎球菌表面抗原A融合蛋白的鼻内免疫诱导对肺炎链球菌定植的保护作用，并且对小鼠鼻咽和口腔微生物群的影响微不足道。
2. Intranasal Immunization with Recombinant Ascaris suum14-Kilodalton Antigen Coupled with Cholera Toxin B Subunit Induces Protective Immunity to A. suum Infection in Mice [J] . Naotoshi Tsuji, Kayo Suzuki, Harue Kasuga-Aoki, Infection and immunity . 2001,第12期

机译：重组猪A虫suum14-Kilodalton抗原与霍乱毒素B亚基的鼻内免疫诱导对小鼠A. suum感染的保护性免疫。
3. Intranasal immunization with coxsackievirus A16 virus-like particles confers protection against lethal infection in neonatal mice [J] . Xiangpeng Chen, Yong Zhang, Naiying Mao, Archives of virology . 2019,第12期

机译：用CoxSackeivirus A16病毒样颗粒鼻内免疫赋予新生儿小鼠的致死感染保护
4. Intranasal immunization with codon optimized MOMP DNA vaccine confers protection against Chlamydia trachomatis infection [C] . Yan Zheng, Wei-Ming Zhao, Hong Wang, International Forum on Progress on Post-Genome Technologies(5'IFPT); 20070910-11; Suzhou(CN) . 2007

机译：经密码子优化的MOMP DNA疫苗进行鼻内免疫可预防沙眼衣原体感染
5. Cloning and evaluation of Vibrio cholerae surface proteins in conferring protection against experimental cholera. [D] . Das, Margaret. 1998

机译：霍乱弧菌表面蛋白的克隆和评估，以赋予对实验霍乱的保护作用。
6. Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection [O] . Charlotte Larsson, Jan Holmgren, Gunnar Lindahl, 2004

机译：B组链球菌蛋白肋骨和霍乱毒素B亚基对小鼠的鼻内免疫可预防致命感染。
7. Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection [O] . Larsson, Charlotte, Holmgren, Jan, Lindahl, Gunnar, 2004

机译：B组链球菌蛋白肋骨和霍乱毒素B亚基对小鼠的鼻内免疫可预防致命感染。

Intranasal Immunization of Mice with Group B Streptococcal Protein Rib and Cholera Toxin B Subunit Confers Protection against Lethal Infection

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