Genetic complementation of defects in vaccine-induced immunity against Schistosoma mansoni in P- and A-strain inbred mice.

R Correa-Oliveira; S L James; A Sher

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Genetic complementation of defects in vaccine-induced immunity against Schistosoma mansoni in P- and A-strain inbred mice.

机译：P和A系近交小鼠疫苗诱导的曼氏血吸虫免疫性缺陷的遗传互补。

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Inbred P- and A-strain mice are deficient in their capacity to develop resistance to challenge infection in response to vaccination with irradiated cercariae of Schistosoma mansoni and are also defective in their cell-mediated response as assessed by the activity of antigen-elicited macrophages in killing schistosome larvae in vitro. In contrast, vaccinated (P x A)F1 mice displayed high levels of both immunity to challenge and macrophage larvicidal activity, indicating that the P- and A-strain defects in the vaccine-induced response are controlled by distinct genetic loci.

机译：自交系P和A株小鼠对曼氏血吸虫辐射后尾的疫苗接种产生抵抗攻击感染的抵抗力的能力不足，并且通过抗原诱导的巨噬细胞的活性评估其细胞介导的反应也有缺陷。在体外杀死血吸虫幼虫。相反，接种过疫苗的（P x A）F1小鼠对攻击和巨噬细胞幼虫活动均显示出高水平的免疫力，表明疫苗诱导的应答中的P和A株缺陷由不同的遗传基因座控制。

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《Infection and immunity》 |1988年第3期|共3页
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R Correa-Oliveira; S L James; A Sher;
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中图分类医学免疫学;
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1. Genetic association of defects in macrophage larvicidal activity and vaccine-induced resistance to Schistosoma mansoni in P strain mice. [J] . S L James, R Correa-Oliveira, A Sher, Infection and immunity . 1987,第8期

机译：P株小鼠巨噬细胞杀幼虫活性缺陷和疫苗诱导的曼氏血吸虫耐药性的遗传关联。
2. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. [J] . Hoffmann KF, James SL, Cheever AW, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1999,第2期

机译：对双重细胞因子缺陷型小鼠的研究表明，高度极化的Th1型和Th2型细胞因子以及抗体反应均同样有助于疫苗诱导的曼氏血吸虫免疫。
3. Morphological tegument alterations of adult Schistosoma mansoni, harbored in non anti-helminthic treated, high-immune-tolerogenic and low-inflammatory mice. [J] . Xavier AM, Magalhaes JA, Cunha Gdos S, Acta tropica: Journal of Biomedical Sciences . 2010,第1期

机译：在非抗蠕虫病治疗的，高免疫耐受性和低炎症性小鼠中具有成年曼氏血吸虫的形态形态变化。
4. Immune attrition of adult Schistosoma mansoni worms and host immune mechanisms stimulated by DNA vaccination with SmCT-SOD, SmGPX, and Sm-filamin. [D] . Cook, Rosemary M. 2004

机译：SmCT-SOD，SmGPX和Sm-filamin的DNA疫苗接种能激发曼氏血吸虫成虫蠕虫的免疫力和宿主免疫机制。
5. Genetic complementation of defects in vaccine-induced immunity against Schistosoma mansoni in P- and A-strain inbred mice. [O] . R Correa-Oliveira, S L James, A Sher 1988

机译：P和A系近交小鼠疫苗诱导的曼氏血吸虫免疫性缺陷的遗传互补。
6. Variação dos níveis do componente C3 do complemento em Holochilus brasiliensis nanus experimentalmente infectados com Schistosoma mansoni Variation in the levels of the C3 component of the complement in Holochilus brasiliensis nanus infected with Schistosoma mansoni [O] . Othon de Carvalho Bastos, Maria Helena Seabra Soares de Brito, Maria Salete Sipauba Schiavotelo, 1984

机译：实验感染曼氏血吸虫的Holochilus brasiliensis nanus补体成分C3水平的变化曼氏血吸虫感染的Holochilus brasiliensis nanus补体补体C3成分水平的变化
7. The Cellular and Humoral Immune Response to 'Schistosoma mansoni' Infections in Inbred Rats. V. Prerequisite Mechanisms for the Development of Optimal Protective Immunity. [R] . Phillips, S. M., Reid, W. A., Doughty, B., 1977

机译：近交系大鼠'曼氏血吸虫'感染的细胞和体液免疫应答。 V.开发最佳保护性免疫的先决条件机制。

Genetic complementation of defects in vaccine-induced immunity against Schistosoma mansoni in P- and A-strain inbred mice.

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