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首页> 外文期刊>Infection and immunity >Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice.
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Correlates of cell-mediated immunity in Candida albicans-colonized gnotobiotic mice.

机译：与白色念珠菌定殖的生真菌小鼠的细胞介导的免疫相关。

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Germfree athymic (nuu) and euthymic (nu/+) mice were colonized with a pure culture of Candida albicans. Correlates of cell-mediated immunity (lymphocyte proliferation and footpad responses to C. albicans antigens) and in vivo clearance of mucosal infections were assessed at different time intervals after alimentary tract colonization. C. albicans hyphae infected the dorsal surface of the tongue and the cardial section of the stomach in both nuu and nu/+ mice within 1 week after colonization with a pure culture of C. albicans. With time after colonization and infection with C. albicans, nu/+ mice manifested positive lymphocyte proliferation and positive footpad responses to Candida antigens that appeared to correlate with the capacity to clear Candida hyphae from the dorsal surface of the tongue and in the stomach. Conversely, nuu mice could not clear mucosal candidosis (in the stomach and on the tongue) and did not manifest either lymphocyte proliferation or footpad swelling in response to C. albicans antigens. These studies indicated that T-cell-mediated immunity may play a role in the acquired resistance of mice to mucosal candidosis. Since neither nuu nor nu/+ mice developed a progressive systemic disease, T cells apparently do not play a prominent role in murine resistance to systemic candidosis of endogenous origin.
机译：用白色念珠菌的纯培养物定殖无生殖性无胸腺（nu / nu）和常态（nu / +）小鼠。在消化道定植后的不同时间间隔，评估细胞介导的免疫力（淋巴细胞增殖和对白色念珠菌抗原的足垫反应）和粘膜感染的体内清除率的相关性。白色念珠菌菌丝在纯白色念珠菌培养物定植后1周内感染了nu / nu和nu / +小鼠的舌背表面和胃的心脏部分。在定植并感染白色念珠菌后，随着时间的流逝，nu / +小鼠表现出对念珠菌抗原的阳性淋巴细胞增殖和足垫阳性反应，这似乎与从舌背表面和胃中清除念珠菌丝的能力有关。相反，nu / nu小鼠不能清除粘膜念珠菌病（在胃和舌头），也没有表现出对白念珠菌抗原反应的淋巴细胞增殖或足垫肿胀。这些研究表明，T细胞介导的免疫可能在小鼠对粘膜念珠菌病的获得性耐药中起作用。由于nu / nu和nu / +小鼠均未发展为进行性全身性疾病，因此T细胞显然在鼠类对内源性系统性念珠菌病的抗性中没有发挥重要作用。

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