Relative abilities of distinct isotypes of human major histocompatibility complex class II molecules to bind streptococcal pyrogenic exotoxin types A and B.

K Imanishi; H Igarashi; T Uchiyama

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Relative abilities of distinct isotypes of human major histocompatibility complex class II molecules to bind streptococcal pyrogenic exotoxin types A and B.

机译：人类主要组织相容性复合物II类分子的不同同种型结合链球菌热原性外毒素A型和B型的相对能力。

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The relative ability of distinct isotypes of human leukocyte antigen class II molecules to bind streptococcal pyrogenic exotoxins A and B (SPE A and SPE B, respectively) was investigated by a direct-binding assay with 125I-labeled toxin for SPE A and by a functional assay system measuring the accessory cell activity of human leukocyte antigen class II transfectants in toxin-induced T-cell activation for SPE A and SPE B. SPE A binding was observed in L cells transfected with DQw1 genes. By contrast, it was not detected in L cells transfected with DR2, DR4, DPw4 or DP(Cp63) genes. All the transfectants supported SPE-induced interleukin-2 production by human T cells except the DP transfectants for SPE B. Levels of accessory cell activity were low in the DP transfectants induced by stimulation with SPE A and in the DR and DP transfectants induced by SPE B. The results indicate that SPE A and SPE B bind well to DQ molecules, less well to DR molecules, and very weakly to DP molecules.

机译：通过直接结合试验，使用125I标记的SPE A毒素和功能性抗体，研究了人类白细胞抗原II类分子不同同种型结合链球菌热原性外毒素A和B（分别为SPE A和SPE B）的相对能力。检测系统，用于测量人白细胞抗原II类转染子在毒素诱导的SPE A和SPE B的T细胞活化中的辅助细胞活性。在用DQw1基因转染的L细胞中观察到SPE A结合。相反，在用DR2，DR4，DPw4或DP（Cp63）基因转染的L细胞中未检测到它。除用于SPE B的DP转染子外，所有转染子均支持人T细胞产生SPE诱导的白介素2。在用SPE A刺激诱导的DP转染子中以及在SPE诱导的DR和DP转染子中，辅助细胞活性水平较低。 B.结果表明，SPE A和SPE B与DQ分子的结合良好，与DR分子的结合较差，而与DP分子的结合则较弱。

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《Infection and immunity》 |1992年第12期|共5页
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K Imanishi; H Igarashi; T Uchiyama;
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中图分类医学免疫学;
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Relative abilities of distinct isotypes of human major histocompatibility complex class II molecules to bind streptococcal pyrogenic exotoxin types A and B.

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