Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice.

L E Bermudez; J Champsi

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Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice.

机译：鸟分枝杆菌感染会诱导白介素10（IL-10）的产生，抗IL-10抗体的给药与小鼠抗感染能力增强相关。

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Organisms of the Mycobacterium avium complex are associated with disseminated infection in patients with AIDS. The mechanisms that account for the survival of the intracellular bacteria are unknown. We document here that infection of C57BL/6 black mice with M. avium 101 triggered interleukin-10 (IL-10) production. The synthesis of IL-10 peaked after 2 weeks of infection and remained elevated throughout the period of infection. Treatment of M. avium-infected peritoneal macrophages with recombinant IL-10 suppressed the stimulatory effect of tumor necrosis factor alpha and granulocyte-macrophage colony-stimulating factor. To confirm the possible role of IL-10 in the infection in vivo, mice were infected with M. avium 101 and simultaneously received treatment with neutralizing anti-IL-10 antibody. After 4 weeks the animals were harvested and the numbers of viable bacteria were quantitated in the liver, spleen, and blood. The liver and spleen of animals receiving anti-IL-10 antibody had 2 to 3 log units fewer bacteria than did those of control animals. These results suggest a role for IL-10 in the pathogenesis of M. avium infection.

机译：鸟分枝杆菌复合物的生物与艾滋病患者的传播感染有关。解释细胞内细菌存活的机制尚不清楚。我们在这里记录到，感染了鸟分枝杆菌101的C57BL / 6黑色小鼠会触发白介素10（IL-10）的产生。 IL-10的合成在感染2周后达到峰值，并在整个感染期间保持升高。用重组IL-10治疗鸟分枝杆菌感染的腹膜巨噬细胞可抑制肿瘤坏死因子α和粒细胞巨噬细胞集落刺激因子的刺激作用。为了证实IL-10在体内感染中的可能作用，小鼠被鸟分枝杆菌101感染并同时接受中和性抗IL-10抗体的治疗。 4周后，收获动物，并定量肝脏，脾脏和血液中的活细菌数量。接受抗IL-10抗体的动物的肝脏和脾脏细菌比对照组动物少2-3个log单位。这些结果表明IL-10在鸟分枝杆菌感染的发病机理中的作用。

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《Infection and immunity》 |1993年第7期|共5页
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L E Bermudez; J Champsi;
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6. Infection with Mycobacterium avium induces production of interleukin-10 (IL-10) and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice. [O] . L E Bermudez, J Champsi 1993

机译：鸟分枝杆菌感染会诱导白介素10（IL-10）的产生抗IL-10抗体的给药与小鼠抗感染能力增强相关。
7. Neutralization of Interleukin-10 Significantly Enhances Gamma Interferon Expression in Peripheral Blood by Stimulation with Johnin Purified Protein Derivative and by Infection with Mycobacterium avium subsp. paratuberculosis in Experimentally Infected Cattle with Paratuberculosis [O] . Buza, Joram J., Hikono, Hirokazu, Mori, Yasuyuki, 2004

机译：通过用Johnin纯化的蛋白衍生物刺激和鸟分枝杆菌亚种感染，白细胞介素10的中和作用显着增强了外周血中的γ干扰素表达。实验感染牛副结核病中的副结核病

Infection with Mycobacterium avium induces production of interleukin-10 (IL-10), and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice.

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