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首页> 外文期刊>Infection and immunity >Morphological evidence for penetration of anti-O antibody through the capsule of Klebsiella pneumoniae.
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Morphological evidence for penetration of anti-O antibody through the capsule of Klebsiella pneumoniae.

机译：抗O抗体穿过肺炎克雷伯菌的胶囊的形态学证据。

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The role of the capsule in the reaction with anti-O or anti-K serum was examined morphologically by the techniques of freeze-substitution and immunoelectron microscopy in two strains of Klebsiella pneumoniae differing in virulence for mice. Strain Chedid (O1:K2), an encapsulated virulent strain, has a thicker capsule (150 nm) than the encapsulated avirulent strain 277 (O1:K2) (60 nm). Two morphologically recognizable domains in the capsule created by the arrangement of the capsular filaments were clearly seen in strain Chedid but were less evident in strain 277. Anti-O antibody could penetrate through the capsular layer of both strains. The capsule has no function as a barrier for the penetration of the antibody. Anti-K antibody reacted only on the surface of the capsule and induced swelling of the capsule.
机译：通过冷冻替代技术和免疫电子显微镜技术，在两种小鼠毒性不同的肺炎克雷伯氏菌菌株中，通过形态学检查了胶囊在与抗O或抗K血清反应中的作用。 Chedid菌株（O1：K2）是一种封装的强毒菌株，其胶囊（150 nm）比封装的无毒力菌株277（O1：K2）（60 nm）厚。在Chedid菌株中清楚地看到了由荚膜细丝排列产生的在胶囊中的两个形态学上可识别的结构域，但在277菌株中却不明显。抗O抗体可以穿透两种菌株的荚膜层。胶囊不具有阻止抗体渗透的功能。抗K抗体仅在胶囊表面反应，并引起胶囊溶胀。

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