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首页> 外文期刊>Infection and immunity >Mouse intravaginal infection with Trichomonas vaginalis and role of Lactobacillus acidophilus in sustaining infection.
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Mouse intravaginal infection with Trichomonas vaginalis and role of Lactobacillus acidophilus in sustaining infection.

机译：阴道阴道毛滴虫的小鼠阴道内感染和嗜酸乳杆菌在持续感染中的作用。

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Recent work with a mouse model of Trichomonas vaginalis infection indicated that only 25% of mice harbor Lactobacillus spp. and that T. vaginalis infection rates fall rapidly after 7 days postinfection. In women infected with T. vaginalis, there is a disruption of the Lactobacillus population, which usually predominates. In an attempt to establish a better mouse intravaginal infection that resembles human disease, we established Lactobacillus acidophilus in estrogenized BALB/c mice. T. vaginalis was then inoculated intravaginally into mice previously infected with L. acidophilus and into mice in an untreated group. From 52 mice, 50-microliters vaginal washes were collected, cultured, and examined daily for live trichomonads after inoculation. Although initial infectivity in the two groups was comparable (79 to 83%), L. acidophilus-infected mice showed greater duration of infection. At day 24 postinfection, 69% of L. acidophilus-infected mice were still infected with T. vaginalis compared with only 11% of untreated mice (P = 0.002). The addition of L. acidophilus did not significantly alter the resident mouse vaginal flora. By the addition of L. acidophilus, the mouse will be valuable for studying factors involved in T. vaginalis infectivity and pathogenicity.
机译：阴道毛滴虫感染小鼠模型的最新研究表明，只有25％的小鼠带有乳杆菌属。感染后7天，阴道锥虫感染率迅速下降。在感染了阴道锥虫的妇女中，乳杆菌种群的破坏通常占主导地位。为了建立更好的类似于人类疾病的小鼠阴道内感染，我们在雌激素化的BALB / c小鼠中建立了嗜酸乳杆菌。然后将阴道锥虫阴道内接种到先前感染过嗜酸乳杆菌的小鼠中，以及未治疗组的小鼠中。从52只小鼠中，收集，培养50微升阴道冲洗液，并在接种后每天检查其是否存在活滴虫。尽管两组的初始感染性相当（79％至83％），但嗜酸乳杆菌感染的小鼠表现出更长的感染持续时间。在感染后第24天，与未经治疗的小鼠中只有11％相比，仍有69％的嗜酸乳杆菌感染的小鼠仍感染了阴道锥虫（P = 0.002）。嗜酸乳杆菌的添加并没有显着改变常驻小鼠阴道菌群。通过添加嗜酸乳杆菌，该小鼠对于研究与阴道锥虫的感染性和致病性有关的因素将是有价值的。

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