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首页> 外文期刊>The American Journal of Tropical Medicine and Hygiene >Use of intravaginal microbicides to prevent acquisition of Trichomonas vaginalis infection in Lactobacillus-pretreated, estrogenized young mice.
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Use of intravaginal microbicides to prevent acquisition of Trichomonas vaginalis infection in Lactobacillus-pretreated, estrogenized young mice.

机译：阴道杀菌剂的使用，以防止在经过乳杆菌预处理的雌激素化幼鼠中获得阴道毛滴虫感染。

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摘要

D2A21, a novel peptide antibiotic has in vitro activity against a wide spectrum of sexually transmitted diseases (STD). In this study we tested the hypothesis that intravaginal D2A21 would interfere with acquisition of Trichomonas vaginalis infection in a modified mouse model. T. vaginalis infections of estrogenized young mice pretreated with Lactobacillus vaginalis or Lactobacillus rhamnosus were more frequent and persistent than those in mice pre-treated with Lactobacillus gasseri or Lactobacillus acidophilus. One hundred percent T. vaginalis infection was achieved for 2-4 days post-challenge when intravaginal L. rhamnosus pre-treatments were given to estrogenized mice 48 hr prior to a single T. vaginalis challenge. Estrogenized mice pre-treated with L. rhamnosus were pre-medicated with intravaginal placebo gel, 0.5% or 2% D2A21 gel, or 500 microg/mL metronidazole gel prior to T. vaginalis challenge. Both 2% D2A21 and metronidazole gels were significantly more efficacious (10% or none infected) than placebo gel (53% infected) in preventing vaginal T. vaginalis infections in mice.
机译：D2A21是一种新型肽类抗生素，对多种性传播疾病（STD）具有体外活性。在这项研究中，我们测试了在改良的小鼠模型中阴道内D2A21会干扰获得阴道毛滴虫感染的假设。与经加氏乳杆菌或嗜酸乳杆菌预处理的小鼠相比，经阴道乳杆菌或鼠李糖乳杆菌预处理的雌性幼小小鼠的阴道锥虫感染更为频繁和持久。在挑战后的2-4天，对阴道内的鼠李糖乳杆菌进行了一次预处理，在单次挑战阴道粘膜刺激48小时前，对雌激素化的小鼠进行了100％的阴道曲霉感染。用阴道内安慰剂凝胶，0.5％或2％D2A21凝胶或500 microg / mL甲硝唑凝胶对用鼠李糖乳杆菌预处理的雌激素小鼠进行预药物治疗，然后再挑战阴道阴囊。 2％的D2A21和甲硝唑凝胶在预防小鼠阴道T.阴道感染方面比安慰剂凝胶（53％感染）有效（10％或没有感染）。

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