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首页> 外文期刊>Infection and immunity >Effect of hypertriglyceridemia on endotoxin responsiveness in humans.
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Effect of hypertriglyceridemia on endotoxin responsiveness in humans.

机译：高甘油三酸酯血症对人类内毒素反应性的影响。

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Triglyceride-rich lipoproteins can inhibit endotoxin activity in vitro and in rodents. We sought to determine whether Intralipid, a triglyceride-rich fat emulsion which in contact with plasma functions similarly to endogenous lipoproteins, can alter the human response to endotoxin. Intralipid inhibited endotoxin-induced cytokine production in human whole blood in vitro in a dose-dependent manner, with maximal inhibition (up to 70%) being achieved at a concentration of 10 g/liter. In healthy men, a bolus intravenous injection of endotoxin (lot EC-5; 20 U/kg of body weight) was given midway through a 4-h infusion (125 ml/h) of either 5% glucose (n = 5) or 20% Intralipid (n = 5). The infusion of Intralipid led to an increase in triglyceride levels in serum from 95 +/- 16 to 818 +/- 135 mg/dl prior to endotoxin administration, i.e., levels that importantly reduced cytokine production in endotoxin-stimulated whole blood. However, in vivo hypertriglyceridemia did not influence inflammatory responses to endotoxin (fever, release of tumor necrosis factor and soluble tumor necrosis factor receptors, and leukocytosis) or even potentiated endotoxin responses (release of interleukins 6 and 8 and neutrophil degranulation). Hypertriglyceridemia does not inhibit the in vivo responses to endotoxin in humans.
机译：富含甘油三酸酯的脂蛋白可以在体外和啮齿动物中抑制内毒素活性。我们试图确定Intralipid（一种富含甘油三酸酯的脂肪乳剂，与血浆接触的功能类似于内源性脂蛋白）是否可以改变人类对内毒素的反应。脂质体内在体外以剂量依赖性方式抑制人全血中内毒素诱导的细胞因子的产生，浓度为10 g / L时达到最大抑制作用（最高70％）。在健康男性中，在5％葡萄糖（n = 5）输注4小时（125 ml / h）的过程中，静脉推注内毒素（批次EC-5; 20 U / kg体重）。 20％脂质内（n = 5）。内毒素的输注导致内毒素给药前血清甘油三酸酯水平从95 +/- 16增加到818 +/- 135毫克/分升，即重要降低内毒素刺激的全血中细胞因子产生的水平。然而，体内高甘油三酯血症并不影响对内毒素的炎症反应（发烧，肿瘤坏死因子和可溶性肿瘤坏死因子受体的释放以及白细胞增多），甚至不会增强内毒素反应（白细胞介素6和8的释放以及中性粒细胞的脱颗粒）。高甘油三酯血症不会抑制人体内对内毒素的反应。

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