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The Mycobacterium tuberculosis ESAT-6 Homologue in Listeria monocytogenes Is Dispensable for Growth In Vitro and In Vivo

机译:单核细胞增生李斯特菌中的结核分枝杆菌ESAT-6同源物可用于体内和体外生长

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摘要

ESAT-6 is a virulence determinant in Mycobacterium tuberculosis and a member of a conserved group of proteins in a variety of other bacteria. A targeted deletion of the homologous gene in Listeria was generated, and in contrast to that observed for mycobacteria, this locus was not required for Listeria virulence.
机译:ESAT-6是结核分枝杆菌的毒力决定因素,并且是多种其他细菌中保守的一组蛋白质的成员。有针对性地删除了李斯特菌中的同源基因,与分枝杆菌观察到的相反,李斯特菌的毒力不需要此基因座。

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