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Bacterial and Host Factors Implicated in Nasal Carriage of Methicillin-Resistant Staphylococcus aureus in Mice

机译:细菌和宿主因素与耐甲氧西林金黄色葡萄球菌的鼻腔运输有关

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摘要

Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2)-deficient mice but not TLR4-deficient mice.
机译:鼻腔运输是金黄色葡萄球菌感染的主要危险因素,尤其是耐甲氧西林菌株(MRSA)。使用鼻支架的鼠标模型,我们比较了几个 S。并在囊性纤维化跨膜电导调节剂缺陷型小鼠和Toll样受体2(TLR2)缺陷型小鼠中表现出MRSA升高的定殖水平,而在TLR4缺陷型小鼠中却没有。

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