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首页> 外文期刊>Infection and immunity >Role of Polymorphonuclear Neutrophils in a Murine Model of Chlamydia psittaci-Induced Abortion
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Role of Polymorphonuclear Neutrophils in a Murine Model of Chlamydia psittaci-Induced Abortion

机译：多形核中性粒细胞在鹦鹉热衣原体人工流产小鼠模型中的作用。

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To assess the role of polymorphonuclear neutrophils (PMNs) inChlamydia psittaci infection in a pregnant mouse model, pregnant and nonpregnant Swiss OF1 mice were depleted of PMNs by treatment with the RB6-8C5 monoclonal antibody before intraperitoneal infection with C. psittaci serotype 1. Nondepleted mice served as infection controls. Depleted mice aborted earlier and had a much higher mortality rate than nondepleted mice. Bacteriological analysis showed that the number of chlamydiae isolated from the spleens of depleted mice at 5 and 7 days postinfection was 100 times greater than that isolated from nondepleted mice. Histopathological analysis of the placentas of depleted mice showed widespread necrosis of the uteroplacental units, with weak immunoreaction to chlamydial antigen, while the placentas of nondepleted mice showed substantial neutrophil infiltration but no large areas of necrosis, with moderate to strong immunoreaction to chlamydial antigen. The livers of depleted mice showed numerous chlamydial inclusions in the hepatocytes, delayed microgranuloma formation, and in the pregnant animals extensive coagulative periportal necrosis. The livers of nondepleted mice displayed multiple small foci of PMNs and mononuclear cells with microgranuloma formation. Among this group of mice, the pregnant animals always had more hepatic damage than nonpregnant animals. Our results suggest that PMNs play an essential role in the response to C. psittaci primary infection, preventing the uncontrolled multiplication of chlamydiae in the liver and spleen.
机译：为了评估多形核中性粒细胞（PMNs）在怀孕小鼠模型中的鹦鹉热衣原体感染中的作用，在腹膜内感染之前，通过用RB6-8C5单克隆抗体处理来消除怀孕和未怀孕的Swiss OF1小鼠的PMN。 C。 psittaci 血清型1.未耗尽的小鼠作为感染对照。耗竭的小鼠比不耗竭的小鼠更早流产，并且死亡率更高。细菌学分析表明，在感染后第5天和第7天从贫血小鼠的脾脏分离出的衣原体数量是从非贫血小鼠分离出的衣原体数量的100倍。对耗竭小鼠的胎盘的组织病理学分析显示，子宫胎盘单位广泛坏死，对衣原体抗原的免疫反应较弱，而未耗竭小鼠的胎盘显示出中性粒细胞大量浸润，但没有大面积坏死，对衣原体抗原的免疫反应中等至强。耗竭小鼠的肝脏在肝细胞中显示出大量衣原体包涵体，延迟了微肉芽肿的形成，在怀孕的动物中广泛的凝集性门静脉周围坏死。未耗尽小鼠的肝脏显示出多个小灶性PMN和单核细胞，并形成了微肉芽肿。在这组小鼠中，怀孕的动物总是比未怀孕的动物有更多的肝损伤。我们的结果表明，PMN在对 C的响应中起着至关重要的作用。 psittaci 原发感染，可防止衣原体在肝脏和脾脏中不受控制地繁殖。

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