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首页> 外文期刊>Infection and immunity >Adaptive Immune Response to Shigella flexneri 2acydC in Immunocompetent Mice and Mice Lacking Immunoglobulin A
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Adaptive Immune Response to Shigella flexneri 2acydC in Immunocompetent Mice and Mice Lacking Immunoglobulin A

机译:免疫适应性小鼠和缺乏免疫球蛋白A的小鼠对弗氏志贺氏菌2acydC的适应性免疫反应

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摘要

Shigella flexneri cydC, which is deficient in cytochrome bd, was rapidly cleared from the lungs of intranasally inoculated mice and was Sereny negative, yet it induced 93% protection against challenge with wild-type S. flexneri. Mice that lack immunoglobulin A (IgA) were fully protected, suggesting that IgA may not be required for adaptive immunity in this model system.
机译:缺乏细胞色素 bd 弗氏志贺氏菌cydC 可从鼻内接种小鼠的肺中迅速清除,并且是Sereny阴性的,但是它诱导了93%的保护免受野生动物攻击类型 S。 flexneri 。缺乏免疫球蛋白A(IgA)的小鼠得到了充分的保护,这表明该模型系统中的适应性免疫可能不需要IgA。

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