Killing of Borrelia burgdorferi by Antibody Elicited by OspA Vaccine Is Inefficient in the Absence of Complement

Jena M. Nowling; Mario T. Philipp

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Killing of Borrelia burgdorferi by Antibody Elicited by OspA Vaccine Is Inefficient in the Absence of Complement

机译：在缺乏补体的情况下，用OspA疫苗激发的抗体杀死博氏疏螺旋体是无效的

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A Lyme disease vaccine, based on the Borrelia burgdorferi lipoprotein OspA, has recently undergone phase III trials in humans. The results of one of these trials indicate that vaccine efficacy positively correlates with anti-OspA antibody titer. Spirochete killing within the tick vector midgut, upon which vaccine efficacy appears to depend, may occur chiefly via a mechanism that involves antibody alone, as it has been reported that complement is degraded by tick saliva decomplementing factors. We compared the in vitro killing efficiencies of anti-OspA antibody elicited in rhesus monkeys by the OspA vaccine, in the presence and in the absence of monkey complement. Killing in the absence of complement was between 14 and 3,800 times less efficient than with complement present, depending on the spirochete strain. The relative inefficiency of the complement-independent killing mechanism by anti-OspA antibody may explain why OspA vaccine efficacy is critically dependent on antibody titer.

机译：一种基于 Borrelia burgdorferi 脂蛋白OspA的莱姆病疫苗最近已在人类中进行了III期试验。这些试验之一的结果表明疫苗效力与抗OspA抗体效价呈正相关。滴虫载体中肠内的螺旋藻杀伤可能是疫苗效力所依赖的，主要通过仅涉及抗体的机理进行杀伤力，因为据报道补体被滴虫唾液去补体因子降解。我们比较了在有和没有猴子补体的情况下，OspA疫苗在恒河猴中引发的抗OspA抗体的体外杀伤效率。在不存在补体的情况下进行杀死的效率要比在存在补体的情况下降低14至3800倍，具体取决于螺旋体菌株。抗OspA抗体对补体依赖性杀伤机制的相对效率低下，可以解释为什么OspA疫苗的功效关键取决于抗体效价。 展开▼

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《Infection and immunity》 |1999年第1期|共3页

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Jena M. Nowling; Mario T. Philipp;
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专利

1. Borrelia burgdorferi Escape Mutants That Survive in the Presence of Antiserum to the OspA Vaccine Are Killed When Complement Is Also Present [J] . Mónica Solé, Carlos Bantar, Karl Indest, Infection and immunity . 1998,第6期

机译：当还存在补体时，在OspA疫苗抗血清存在下存活的疏螺旋体疏螺旋体被杀死。

2. An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis. [J] . B Wilske, V Preac-Mursic, U B G?bel, Journal of Clinical Microbiology . 1993,第2期

机译：基于与单克隆抗体的反应性和OspA序列分析的伯氏疏螺旋体的OspA血清分型系统。

3. An OspA serotyping system for Borrelia burgdorferi based on reactivity with monoclonal antibodies and OspA sequence analysis. [J] . B Wilske, V Preac-Mursic, U B G?bel, Journal of Clinical Microbiology . 1993,第2期

机译：基于与单克隆抗体的反应性和OspA序列分析的伯氏疏螺旋体的OspA血清分型系统。

4. SEROPREVALENCE OF ANTIBODIES TO ANAPLASMA PHAGOCYTOPHILUM AND BORRELIA BURGDORFERI IN DOMESTIC CATS [C] . Jill Saucier, Bryan Leonard, Kristine Hoyt, Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：在国内猫体猫畜吞噬细胞和Borrelia Burgdorferi的抗体的Seroprevalence

5. Borrelia burgdorferi Outer surface protein A (OspA): A tick transmission factor and a Lyme disease vaccine. [D] . Gipson, Clay Livingston. 2004

机译：伯氏疏螺旋体（Borrelia burgdorferi）外表面蛋白A（OspA）：tick传播因子和莱姆病疫苗。

6. Note: Killing of Borrelia burgdorferi by Antibody Elicited by OspA Vaccine Is Inefficient in the Absence of Complement [O] . Jena M. Nowling, Mario T. Philipp 1999

机译：注意：在没有补体的情况下用OspA疫苗诱发的抗体杀死博氏疏螺旋体效率低下

7. Borrelia burgdorferi Escape Mutants That Survive in the Presence of Antiserum to the OspA Vaccine Are Killed When Complement Is Also Present [O] . Mónica Solé, Carlos Bantar, Karl Indest, 1998

机译：在补充也存在时，Borrelia Burgdorferi逃生突变体在抗血清存在下存活的突变体遭到杀害

8. Use of T7 RNA polymerase to direct expression of outer Surface Protein A (OspA) from the Lyme disease Spirochete, Borrelia burgdorferi [R] . Dunn, John J., Lade, Barbara N. 1991

机译：T7 RNa聚合酶的使用，以引导来自莱姆病螺旋体，伯氏疏螺旋外表面蛋白a（的Ospa）的表达

1. 聚合酶链反应检测进行性特发性皮肤萎缩中博氏疏螺旋体DNA [J] . 马东来 ,周光霁 . 中华皮肤科杂志 . 1996,第006期

2. 博氏疏螺旋体与局限性硬皮病 [J] . 马东来 . 国外医学：皮肤性病学分册 . 1996,第002期

3. 用原位聚合酶链反应方法检测结节病病理组织中博氏疏螺旋体的研究 [J] . 汪谋岳 . 中华医学信息导报 . 1996,第020期

4. 用聚合酶链反应检测结节病患者标本中的博氏疏螺旋体 [J] . 连伟 ,罗慰慈 . 中华内科杂志 . 1995,第007期

5. 结节病病人血清抗布氏疏螺旋体抗体测定及其意义 [J] . 陈燕启 ,张秀珍 . 中华内科杂志 . 1994,第001期

6. 仔猪大肠埃希氏菌病三价灭活疫苗免疫蛋鸡后血清抗体与卵黄抗体变化规律的研究 [C] . . 中国畜牧兽医学会动物传染病学分会第三届猪病防控学术研讨会 . 2008

7. 伽氏疏螺旋体P66基因的特征与抗原性研究 [A] . 于培发 . 2016

1. 伽氏疏螺旋体OspA蛋白C端肽段及其应用 [P] . 中国专利： CN110483624A . 2019-11-22

2. 用于检测博氏疏螺旋体的生物测定 [P] . 中国专利： CN1061245A . 1992-05-20

3. DNA fragment encoding OspA of Borrelia burgdorferi, vaccine and diagnostics comprising OspA encoded by the DNA fragment [P] . 外国专利： EP0565208A1 . 1993-10-13

机译：编码博氏疏螺旋体的OspA的DNA片段，疫苗和包含该DNA片段编码的OspA的诊断试剂

4. DNA encoding borrelia burgdorferi OspA and a method for diagnosing borrelia burgdorferi infection [P] . 外国专利： US5582990A . 1996-12-10

机译：编码伯氏疏螺旋体OspA的DNA和诊断伯氏疏螺旋体感染的方法

5. Borrelia burgdorferi immunologically active proteins, test kits containing these proteins and suitable for detecting antibodies in test liquids, monoclonal antibodies directed against the immunologically active proteins and the use of these proteins as vaccines against infections caused by Borrelia strains [P] . 外国专利： DE4018988C2 . 1999-07-08

机译：伯氏疏螺旋体具有免疫活性的蛋白质，包含这些蛋白质的检测试剂盒以及适用于检测检测液体中的抗体的试剂盒，针对具有免疫活性的蛋白质的单克隆抗体以及将这些蛋白质用作抵抗由疏螺旋体菌株引起的感染的疫苗的用途

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Killing of Borrelia burgdorferi by Antibody Elicited by OspA Vaccine Is Inefficient in the Absence of Complement

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