In Vivo Genetic Analysis Indicates That PhoP-PhoQ and the Salmonella Pathogenicity Island 2 Type III Secretion System Contribute Independently to Salmonella enterica Serovar Typhimurium Virulence

Carmen R. Beuzón; Kate E. Unsworth; David W. Holden

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In Vivo Genetic Analysis Indicates That PhoP-PhoQ and the Salmonella Pathogenicity Island 2 Type III Secretion System Contribute Independently to Salmonella enterica Serovar Typhimurium Virulence

机译：体内遗传学分析表明PhoP-PhoQ和沙门氏菌致病岛2型III分泌系统独立地贡献于肠杆菌沙门氏菌鼠伤寒沙门氏菌毒力。

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Many virulence factors are required for Salmonella enterica serovar Typhimurium to replicate intracellularly and proliferate systemically within mice. In this work, we have carried out genetic analyses in vivo to determine the functional relationship between two major virulence factors necessary for systemic infection byS. enterica serovar Typhimurium: theSalmonella pathogenicity island 2 (SPI-2) type III secretion system (TTSS) and the PhoP-PhoQ two-component regulatory system. Although previous work suggested that PhoP-PhoQ regulates SPI-2 TTSS gene expression in vitro, in vivo competitive analysis of mutant strains indicates that these systems contribute independently toS. typhimurium virulence. Our results also suggest that mutation of phoP may compensate partially for defects in the SPI-2 TTSS by deregulating SPI-1 TTSS expression. These results provide an explanation for previous reports showing an apparent functional overlap between these two systems in vitro.

机译：鼠伤寒沙门氏菌鼠伤寒沙门氏菌需要多种毒力因子才能在小鼠内细胞内复制和系统增殖。在这项工作中，我们在体内进行了遗传分析，以确定 S全身感染所必需的两个主要毒力因子之间的功能关系。鼠伤寒肠球菌：沙门氏菌致病岛2（SPI-2）III型分泌系统（TTSS）和PhoP-PhoQ两组分调节系统。尽管以前的工作表明PhoP-PhoQ可以在体外调节SPI-2 TTSS基因的表达，但对突变株的体内竞争分析表明，这些系统独立地对em起作用。鼠伤寒毒力。我们的研究结果还表明， phoP 的突变可通过放松SPI-1 TTSS表达来部分弥补SPI-2 TTSS中的缺陷。这些结果为以前的报告提供了解释，这些报告显示了这两个系统在体外的明显功能重叠。 展开▼

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《Infection and immunity》 |2001年第12期|共8页

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Carmen R. Beuzón; Kate E. Unsworth; David W. Holden;
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1. The Salmonella pathogenicity island 1 and Salmonella pathogenicity island 2 type III secretion systems play a major role in pathogenesis of systemic disease and gastrointestinal tract colonization of Salmonella enterica serovar Typhimurium in the chi [J] . Jones MA, Hulme SD, Barrow PA, Avian Pathology . 2007,第3期

机译：沙门氏菌致病岛1和沙门氏菌致病岛2 III型分泌系统在系统性疾病的发病机理和肠炎沙门氏菌血清鼠伤寒中的胃肠道定殖中起主要作用

2. Evaluation of the role of SsaV Salmonella pathogenicity island-2 dependent type III secretion system components on the virulence behavior of Salmonella enterica serovar Typhimurium [J] . Wael A. H. Hegazy, Hisham A. Abbas African Journal of Biotechnology . 2017,第14期

机译：评估SsaV沙门氏菌致病岛2依赖的III型分泌系统组分对肠炎沙门氏菌鼠伤寒沙门氏菌毒力行为的作用

3. Corrigendum: Secretion of Salmonella Pathogenicity Island 1-Encoded Type III Secretion System Effectors by Outer Membrane Vesicles in Salmonella Enterica Serovar Typhimurium [J] . Seul I Kim, Seongok Kim, Eunsuk Kim, Frontiers in Microbiology . 2019,第6期

机译：更正：沙门氏菌肠炎沙门氏菌外膜囊泡分泌沙门氏菌致病岛1-编码的III型分泌系统效应子。

4. GC-MS-based comparative metabolomics analysis of pathogenic Salmonella enterica serovar Typhimurium grown under host environment conditions [C] . Young-Mo Kim, Heather M. Brewer, Afshan Kidwai, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：基于GC-MS的比较代谢组织分析对宿主环境条件下的致病性沙门氏菌肠道肠杆菌毒蕈

5. Molecular characterization of the Salmonella enterica pathogenicity island 1 (SPI-1)-associated genes and the type III secretion system 1 effector protein SipF [D] . Pancetti, Alessandra Roque. 2004

机译：肠道沙门氏菌致病岛1（SPI-1）相关基因和III型分泌系统1效应蛋白SipF的分子表征。

6. In Vivo Genetic Analysis Indicates That PhoP-PhoQ and the Salmonella Pathogenicity Island 2 Type III Secretion System Contribute Independently to Salmonella enterica Serovar Typhimurium Virulence [O] . Carmen R. Beuzón, Kate E. Unsworth, David W. Holden 2001

机译：体内遗传分析表明PhoP-PhoQ和沙门氏菌致病岛2型III分泌系统独立地对肠炎沙门氏菌血清鼠伤寒病毒致病性。

7. In Vivo Genetic Analysis Indicates That PhoP-PhoQ and the Salmonella Pathogenicity Island 2 Type III Secretion System Contribute Independently to Salmonella enterica Serovar Typhimurium Virulence [O] . Beuzón, Carmen R., Unsworth, Kate E., Holden, David W. 2001

机译：体内遗传分析表明，PhoP-PhoQ和沙门氏菌致病岛2型III分泌系统独立地贡献到肠炎沙门氏菌血清鼠伤寒毒力。

1. 鼠伤寒沙门氏菌的毒力因子及其致病机理 [J] . 刘源 ,刘美含 ,王心 . 兽医导刊 . 2020,第006期

2. 鼠伤寒沙门氏菌毒力岛基因 mgtC 和 sopB双重 PCR 检测的研究 [J] . 欧阳本 ,孙振 ,祁克宗 . 华北农学报 . 2013,第003期

3. 沙门氏菌毒力岛及Ⅲ型分泌系统研究进展 [J] . 陈俊 ,蒋文灿 ,谭天 . 中国人兽共患病学报 . 2015,第004期

4. 沙门氏菌毒力岛及其Ⅲ型分泌系统 [J] . 郭伟军 ,崔照琼 ,李华春 . 上海畜牧兽医通讯 . 2006,第005期

5. 沙门氏菌毒力岛及其Ⅲ型分泌系统 [J] . 王效义 ,杨瑞馥 . 生物技术通讯 . 2004,第002期

6. 不同来源沙门氏菌对小鼠致病力的比较研究及毒力基因的检测分析 [C] . 程琼 ,庞瑞亮 ,王若晨 . 中国畜牧兽医学会动物传染病学分会第十二次人兽共患病学术研讨会暨第六届第十四次教学专业委员会会议 . 2012

7. 致病性大肠杆菌、沙门氏菌毒力岛双重PCR方法建立与应用 [A] . 邹兰 . 2012

1. METHOD FOR INSTANT EXCLUSION OF SALMONELLOSIS AND GENETIC TYPING OF SALMONELLA ENTERICA ENTERITIDIS AND SALMONELLA ENTERICA TYPHIMURIUM WITH MULTIPLEX PCR [P] . 外国专利： UA85804U . 2013-11-25

机译：多重PCR即时排除肠炎沙门氏菌和肠型沙门氏菌的沙门氏菌病和基因分型的方法

2. Use of Salmonella enterica ssp. enterica serovar Typhimurium antigens for serological differentiation of infected and vaccinated pigs [P] . 外国专利： CZ20131048A3 . 2015-04-22

机译：使用沙门氏菌小肠沙门氏菌。肠炎血清鼠伤寒抗原用于感染猪和疫苗接种猪的血清学区分

3. Use of Salmonella enterica ssp. enterica serovar Typhimurium antigens for serological differentiation of infected and vaccinated pigs [P] . 外国专利： CZ305077B6 . 2015-04-22

机译：使用沙门氏菌小肠沙门氏菌。肠炎血清鼠伤寒抗原用于感染猪和疫苗接种猪的血清学区分

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In Vivo Genetic Analysis Indicates That PhoP-PhoQ and the Salmonella Pathogenicity Island 2 Type III Secretion System Contribute Independently to Salmonella enterica Serovar Typhimurium Virulence

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