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Deletion of a Vibrio cholerae ClC Channel Results in Acid Sensitivity and Enhanced Intestinal Colonization

机译:霍乱弧菌ClC通道的删除导致酸敏感性和增强的肠道定植

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ClC chloride channels are found in all three kingdoms of life though little is known about their functions in prokaryotes. Here we investigated the role of a Vibrio cholerae ClC channel in acid resistance and intestinal colonization. The putative V. cholerae ClC channel was found to confer mild resistance to acid when pH was adjusted with HCl, but not with other acids. Surprisingly, a ClC channel deletion mutant exhibited enhanced intestinal colonization in infant mice.
机译:ClC氯化物通道存在于所有三个生命王国中,尽管对其原核生物的功能知之甚少。在这里,我们研究了霍乱弧菌 ClC通道在耐酸和肠道定居中的作用。推定的 V。当用HCl调节pH时,发现霍乱ClC通道对酸具有适度的抗性,而其他酸则没有。令人惊讶地,ClC通道缺失突变体在婴儿小鼠中表现出增强的肠道定植。

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