Differential Interleukin-8 and Nitric Oxide Production in Epithelial Cells Induced by Mucosally Invasive and Noninvasive Trypanosoma cruzi Trypomastigotes

C. S. Eickhoff; L. Eckmann; D. F. Hoft

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Differential Interleukin-8 and Nitric Oxide Production in Epithelial Cells Induced by Mucosally Invasive and Noninvasive Trypanosoma cruzi Trypomastigotes

机译：粘膜侵袭性和非侵袭性锥虫锥虫引起的上皮细胞差异性白介素8和一氧化氮的产生

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Trypanosoma cruzi metacyclic trypomastigotes (MT), but not blood form trypomastigotes (BFT), are highly mucosally infective. We investigated the abilities of MT and BFT to induce inflammation and/or intracellular killing activity within mucosal epithelia. BFT, but not MT, induced marked increases in interleukin-8, GRO-α, MCP-1, and nitric oxide production in HeLa and AGS cells, despite similar infectivities. MT may avoid induction of inflammation as an important biological mechanism facilitating mucosal invasion.

机译：克鲁斯氏锥虫环类锥虫（MT）而非血型锥虫（BFT）具有很高的粘膜感染性。我们调查了MT和BFT诱导粘膜上皮内炎症和/或细胞内杀伤活性的能力。尽管感染性相似，但BFT而非MT诱导HeLa和AGS细胞中白细胞介素8，GRO-α，MCP-1和一氧化氮的产生显着增加。 MT可避免引起炎症，因为炎症是促进粘膜浸润的重要生物学机制。 展开▼

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《Infection and immunity》 |2003年第9期|共4页

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C. S. Eickhoff; L. Eckmann; D. F. Hoft;
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中图分类医学免疫学;

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1. Trypanosoma cruzi: serum levels of nitric oxide and expression of inducible nitric oxide synthase in myocardium and spleen of dogs in the acute stage of infection with metacyclic or blood trypomastigotes. [J] . Vieira P. M. de A., Francisco A. F., Souza S. M. de, Experimental parasitology . 2009,第1期

机译：克鲁斯氏锥虫：在感染了多环或血锥虫的急性期犬的心肌和脾脏中，一氧化氮的血清水平和诱导型一氧化氮合酶的表达。

2. Invasion of MDCK epithelial cells with altered expression of Rho GTPases by Trypanosoma cruzi amastigotes and metacyclic trypomastigotes of strains from the two major phylogenetic lineages [J] . Adriana B. Fernandes, Renato A. Mortara Microbes and infection . 2004,第5期

机译：克氏锥虫和两种亚种的系统性结直肠锥虫感染Rho GTPases表达改变的MDCK上皮细胞

3. Involvement of Trypanosoma cruzi Metacyclic Trypomastigote Surface Molecule gp82 in Adhesion to Gastric Mucin and Invasion of Epithelial Cells [J] . Ivan Neira, Fernando A. Silva, Mauro Cortez, Infection and immunity . 2003,第1期

机译：锥虫锥虫亚环锥虫表面分子gp82参与粘附胃粘膜和侵袭上皮细胞。

4. Trypanosoma cruzi infection induces nitric oxide production and S-nitrosylation of cellular FLIP in host cells [C] . Shimada J., Hatabu T. International Congress of Parasitology . 2010

机译：胰蛋白酶瘤Cruzi感染诱导宿主细胞中细胞翻转的一氧化氮产生和S-亚硝基化

5. Molecular characterization of Trypanosoma cruzi and shed vesicle components involved in host immunomodulation and cell invasion. [D] . Nakayasu, Ernesto Satoshi. 2008

机译：克氏锥虫和脱落的囊泡成分的分子特征涉及宿主的免疫调节和细胞侵袭。

6. Differential Interleukin-8 and Nitric Oxide Production in Epithelial Cells Induced by Mucosally Invasive and Noninvasive Trypanosoma cruzi Trypomastigotes [O] . C. S. Eickhoff, L. Eckmann, D. F. Hoft 2003

机译：粘膜侵袭性和非侵袭性锥虫锥虫诱生的上皮细胞中差异性白介素8和一氧化氮的产生

7. Differential Interleukin-8 and Nitric Oxide Production in Epithelial Cells Induced by Mucosally Invasive and Noninvasive Trypanosoma cruzi Trypomastigotes [O] . Eickhoff, C. S., Eckmann, L., Hoft, D. F. 2003

机译：粘膜侵袭性和非侵袭性锥虫锥虫鞭毛鞭毛虫诱导的上皮细胞差异性白介素8和一氧化氮的产生

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6. 功能性鼻内窥镜手术加药物灌注治疗非侵袭性真菌性鼻窦炎的临床观察 [C] . 解晶辉 ,任树北 ,韩红威 . 2015临床急症经验交流高峰论坛 . 2015

7. 侵袭性与非侵袭性垂体泌乳素腺瘤Mi-RNA的差异表达 [A] . 宋毅 . 2015

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机译：细胞培养液/气室装置及相关方法，以及在正常和囊性纤维化呼吸道上皮细胞分化培养物中测量气态一氧化氮累积的示范用途

5. CELL CULTURE LIQUID/GAS-PHASE CHAMBER DEVICES AND RELATED METHODS, AND EXEMPLARY USE FOR MEASURING ACCUMULATION OF GAS-PHASE NITRIC OXIDE IN DIFFERENTIATED CULTURES OF NORMAL AND CYSTIC FIBROSIS AIRWAY EPITHELIAL CELLS [P] . 外国专利： WO2013106403A1 . 2013-07-18

机译：细胞培养液/气室装置及相关方法，以及在正常和囊性纤维化呼吸道上皮细胞分化培养物中测量气态一氧化氮累积的示范用途

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Differential Interleukin-8 and Nitric Oxide Production in Epithelial Cells Induced by Mucosally Invasive and Noninvasive Trypanosoma cruzi Trypomastigotes

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